Results 21 to 30 of about 35,899 (261)

Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants. [PDF]

PLoS ONE, 2013
Our objective was to investigate diverse clinical antecedents of total and regional brain volume abnormalities and white matter hyperintensity volume on term MRI in extremely low birth weight (birth weight ≤1000 g) survivors.
Nehal A Parikh, Robert E Lasky, Kathleen A Kennedy, Georgia McDavid, Jon E Tyson   +4 more
doaj   +1 more source

THE STATE OF CELLULAR AND HUMORAL IMMUNITY IN INFANTS BORN WITH EXTREMELY LOW AND VERY LOW WEIGHT

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Objective: to study the features of formation of the cellular and humoral parts of the immune system in premature infants with extremely low and very low birth weight. It has been established that the peculiarities of humoral reactivity in extremely low
Devyaltovskaya M. G, Simchenko A. V., Kramko D. A.   +2 more
doaj   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Predictors of early neonatal mortality in extremely low birth weight infants in a Neonatal Intensive Care Unit over a 10-year period

Journal of Pediatric and Neonatal Individualized Medicine, 2020
Background: Early neonatal mortality (ENM) contributes substantially to overall mortality rates. Reliable cause-specific data are valuable; thus, the definition of risk factors provides information on antenatal, perinatal and immediate neonatal ...
Ilias Chatziioannidis, Georgios Mitsiakos, Paraskevi Karagianni, Christos Tsakalidis, Aikaterini Dimopoulou   +4 more
doaj   +1 more source

Risk Factors for Extubation Failure in Extremely Low Birth Weight Infants

Pediatrics and Neonatology, 2017
Although antenatal steroids and early use nasal continuous positive airway pressure (NCPAP) have significantly improved outcomes of neonatal respiratory distress syndrome, intubation with ventilator support is still commonly required in extremely low ...
Shih-Hsin Wang, Jyun-You Liou, Chien-Yi Chen, Hung-Chieh Chou, Wu-Shiun Hsieh, Po-Nien Tsao   +5 more
doaj   +1 more source

Predictive factors for extubation success in very low and extremely low birth weight preterm infants

Canadian Journal of Respiratory Therapy, 2023
# Background Although invasive mechanical ventilation (IMV) has contributed to the survival of preterm infants with extremely low birth weight (ELBW), it is also associated with unsatisfactory clinical outcomes when used for prolonged periods.
Nilson Willamy Bastos de Souza Júnior, Tathiane Ribeiro Rosa, Jane Cecília Kreling Cerântola, Ligia Silvana Lopes Ferrari, Vanessa Suziane Probst, Josiane Marques Felcar   +5 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Bone Mineral Density According to Dual Energy X-ray Absorptiometry is Associated with Serial Serum Alkaline Phosphatase Level in Extremely Low Birth Weight Infants at Discharge

Pediatrics and Neonatology, 2017
To examine bone mineral density in extremely low birth weight infants at discharge and investigate whether serial measurements of serum alkaline phosphatase (ALP) and phosphate can predict bone mineralization.
Jin Lee, Hyun-Kyung Park, Ja Hye Kim, Yun Young Choi, Hyun Ju Lee   +4 more
doaj   +1 more source