Results 21 to 30 of about 56,039 (156)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Length sensing and control strategies for the LCGT interferometer

, 2012
The optical readout scheme for the length degrees of freedom of the LCGT interferometer is proposed. The control scheme is compatible both with the broadband and detuned operations of the interferometer.
Aso, Yoichi, Miyakawa, Osamu, Somiya, Kentaro   +2 more
core   +1 more source

Towards the Design of Gravitational-Wave Detectors for Probing Neutron-Star Physics [PDF]

, 2018
The gravitational waveform of merging binary neutron stars encodes information about extreme states of matter. Probing these gravitational emissions requires the gravitational-wave detectors to have high sensitivity above 1 kHz.
Martynov, Denis, Miao, Haixing, Yang, Huan   +2 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Reducing Thermal Noise in Future Gravitational Wave Detectors by employing Khalili Etalons

, 2011
Reduction of thermal noise in dielectric mirror coatings is a key issue for the sensitivity improvement in second and third generation interferometric gravitational wave detectors. Replacing an end mirror of the interferometer by an anti-resonant cavity (
Abbott, Acernese, Alexey G. Gurkovsky, Benthem, Bondu, Braginsky, Braginsky, Braginsky, Braginsky, Callen, Daniel Heinert, Evans, Fejer, Gillespie, Gorodetsky, Gurkovsky, Harry, Harry, Harry, Hild, Hild, Holger Wittel, Kamp, Kentaro Somiya, Khalili, Kimble, Kuroda, Landau, Levin, Liu, Lück, Martin, Penn, Penn, Punturo, Ronny Nawrodt, Sergey P. Vyatchanin, Sigg, Solimeno, Somiya, Somiya, Somiya, Stefan Hild, Winkler   +43 more
core   +1 more source

Response of VIRGO detectors to pre-big-bang gravitons [PDF]

, 2001
The sensitivity achievable by a pair of VIRGO detectors to stochastic and isotropic gravitational wave backgrounds produced in pre-big-bang models is discussed in view of the development of a second VIRGO interferometer.
Allen B., Babusci D., Caldwell R., Caron B., Christensen N., D. BABUSCI, Gasperini M., Giovannini M., Giovannini M., Grishchuk L. P., Grishchuk L. P., M. GIOVANNINI, Peebles P. J., Schwartzman V. F., Turner M. S., Vachaspati T.   +15 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The effective antenna noise figure F_a for a vertical loop antenna and its application to extremely low frequency/very low frequency atmospheric noise [PDF]

Radio Science, 2007
Expressions tabulated for the effective antenna noise figure Fa usually assume an electric field antenna, since most measurements of radio noise are made on the electric field of the noise. Furthermore, the International Radio Consultative Committee (CCIR) noise model predictions for Fa are made only for electrically short grounded vertical monopoles ...
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source