Results 221 to 230 of about 10,435,637 (287)

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian   +8 more
wiley   +1 more source

Experiments on Nonlocal Fluid‐Flow Metamaterials

open access: yesAdvanced Science, EarlyView.
A nonlocal fluid‐flow metamaterial composed of standard microfluidic tubes and connectors is designed. Hence, the current of the system at one position depends on the gradient of fluid flow at many other positions, leading to unusual alternating backward and forward laminar flows of water.
Ke Wang, Yi Chen, Martin Wegener
wiley   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

open access: yesAdvanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia   +8 more
wiley   +1 more source

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy

open access: yesAdvanced Science, EarlyView.
Awake longitudinal multimodal ultrasound imaging integrates functional ultrasound (fUS), ultrasound localization microscopy (ULM), and functional ULM (fULM) to characterize cerebrovascular function, microvascular architecture, and flow dynamics within the same animals over time.
Zhe Huang   +9 more
wiley   +1 more source

Multiferroic Quantum Criticality in a Proper Ferroelectric Quasi‐one‐dimensional Ising Antiferromagnet

open access: yesAdvanced Science, EarlyView.
Sr1−xBaxCo2V2O8 is established as a magnetic‐ion‐based proper displacive ferroelectric whose transition is continuously suppressed by Ba substitution to a ferroelectric quantum critical point. In the resulting quantum paraelectric regime, a transverse magnetic field induces magnetic quantum criticality, realizing multiferroic quantum criticality and ...
Takayuki Nagai   +3 more
wiley   +1 more source

Bio‐Inspired Gradient Heterogeneous Architectures for Ultrasensitive and Robust Strain Sensors via Programmable Crack Engineering

open access: yesAdvanced Science, EarlyView.
Inspired by the insect campaniform sensillum, a heterogeneous bilayer strain sensor is developed based on a unique impedance mismatch and three‐dimensional structural dynamic percolation strategy. The sensor enables real‐time multi‐joint teleoperation of three joints and the gripper using a six‐degree‐of‐freedom robotic‐arm platform.
Qi Wu   +4 more
wiley   +1 more source

MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation

open access: yesAdvanced Science, EarlyView.
We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui   +18 more
wiley   +1 more source

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