Results 41 to 50 of about 1,246,044 (249)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Multigroup Comparisons with Configural Frequency Analysis

Journal for Person-Oriented Research
Lienert’s (1973) original approach to comparing groups with Configural Frequency Analysis (CFA) cannot straightforwardly be generalized to the comparison of multiple groups.
Alexander von Eye, Wolfgang Wiedermann
doaj   +1 more source

Influence of Cytokines on Inflammatory Eye Diseases: A Citation Network Study [PDF]

, 2022
Beatriz G. Gálvez, Clara Martínez-Pérez, César Villa Collar, Cristina Alvarez‐Peregrina, Miguel Ángel Sánchez‐Tena   +4 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Fertilização In Vitro: Mais de 4 Milhões de Crianças Nascidas e Um Prêmio Nobel

Clinical and Biomedical Research, 2010
Em 1978, nasceu Louise Brown, o primeiro bebê de proveta. Este nascimento histórico foi o resultado de pesquisas do biólogo Robert Edwards e do ginecologista Patrick Steptoe (1).
Helena von Eye Corleta
doaj  

Shotgun metagenomic sequencing analysis of ocular surface microbiome in Singapore residents with mild dry eye [PDF]

, 2022
Louis Tong, Florentin Constancias, Aihua Hou, Song Lin Chua, Daniela I. Drautz‐Moses, Stephan C. Schuster, Liang Yang, Rohan B. H. Williams, Staffan Kjelleberg   +8 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Acute Lymphoblastic Leukemia Relapse Limited to the Anterior Chamber of the Eye and Treated with Novel CAR T-Cell Therapy [PDF]

, 2021
Nir Gomel, Eliya Levinger, Ron Ram, Dror Limon, Zohar Habot‐Wilner   +4 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Investigation of Anti-Myeloperoxidase Antibodies in a Dog with Bilateral Necrotizing Scleritis

Veterinary Sciences, 2015
Necrotizing scleritis is uncommon in dogs and presumed to be immune-mediated. Its clinical pattern and histopathology are similar to ocular lesions observed in humans suffering from granulomatosis with polyangiitis (GPA), formerly named Wegener’s ...
Guillaume Cazalot, Sidonie N. Lavergne
doaj   +1 more source