Results 11 to 20 of about 2,789,483 (285)

Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis

Brain Sciences, 2022
It is generally believed that eye movements are completely spared in amyotrophic lateral sclerosis (ALS). Although a series of eye movement abnormalities has been recognized in recent years, the findings are highly controversial, and bulbar disabilities ...
Xintong Guo, Xiaoxuan Liu, Shan Ye, Xiangyi Liu, Xu Yang, Dongsheng Fan   +5 more
doaj   +4 more sources

Eye movement abnormalities in movement disorders [PDF]

Clinical Parkinsonism & Related Disorders, 2019
The visual system represents the most well-developed sensory system in humans, who are highly dependent on vision for organized response to their environment. The region of eye that is responsible for sharp central vision is the fovea.
Vivek Lal, Daniel Truong
doaj   +5 more sources

Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxP sites.

PLoS ONE, 2014
Eye phenotypes were investigated in Le-Cre(Tg/-); Pax6(fl/+) mice, which were expected to show tissue-specific reduction of Pax6 in surface ectoderm derivatives.
Natalie J Dorà, J Martin Collinson, Robert E Hill, John D West   +3 more
doaj   +3 more sources

Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment

Frontiers in Neurology, 2018
Multiple sclerosis (MS) commonly causes eye movement abnormalities that may have a significant impact on patients’ disability. Inflammatory demyelinating lesions, especially occurring in the posterior fossa, result in a wide range of disorders, spanning ...
Alessandro Serra, Clara G. Chisari, Manuela Matta   +2 more
doaj   +4 more sources

Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome). [PDF]

Genet Med, 2019
A new syndrome with hypotonia, intellectual disability, and eye abnormalities (HIDEA) was previously described in a large consanguineous family. Linkage analysis identified the recessive disease locus, and genome sequencing yielded three candidate genes ...
Rahikkala E, Myllykoski M, Hinttala R, Vieira P, Nayebzadeh N, Weiss S, Plomp AS, Bittner RE, Kurki MI, Kuismin O, Lewis AM, Väisänen ML, Kokkonen H, Westermann J, Bernert G, Tuominen H, Palotie A, Aaltonen L, Yang Y, Potocki L, Moilanen J, van Koningsbruggen S, Wang X, Schmidt WM, Koivunen P, Uusimaa J.   +25 more
europepmc   +2 more sources

Eye Movement Abnormalities in Major Depressive Disorder

Frontiers in Psychiatry, 2021
Background: Despite their high lifetime prevalence, major depressive disorder (MDD) is often difficult to diagnose, and there is a need for useful biomarkers for the diagnosis of MDD.
Junichi Takahashi, Yoji Hirano, Yoji Hirano, Kenichiro Miura, Kentaro Morita, Kentaro Morita, Michiko Fujimoto, Michiko Fujimoto, Hidenaga Yamamori, Hidenaga Yamamori, Hidenaga Yamamori, Yuka Yasuda, Yuka Yasuda, Noriko Kudo, Noriko Kudo, Emiko Shishido, Kosuke Okazaki, Tomoko Shiino, Tomoko Shiino, Tomohiro Nakao, Kiyoto Kasai, Kiyoto Kasai, Ryota Hashimoto, Ryota Hashimoto, Toshiaki Onitsuka   +24 more
doaj   +2 more sources

Eye Movement Abnormalities Can Distinguish First-Episode Schizophrenia, Chronic Schizophrenia, and Prodromal Patients From Healthy Controls

Schizophrenia Bulletin Open, 2023
Background This study attempts to replicate in a Chinese population an earlier UK report that eye movement abnormalities can accurately distinguish schizophrenia (SCZ) cases from healthy controls (HCs).
Hailong Lyu, David St Clair, Renrong Wu   +2 more
exaly   +2 more sources

Eye Movement Abnormalities in Glaucoma Patients: A Review

Eye and Brain, 2022
Matthew A McDonald,1 Clark H Stevenson,1 Hannah M Kersten,2,3 Helen V Danesh-Meyer1,3 1Department of Ophthalmology, University of Auckland, Auckland, New Zealand; 2School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand ...
McDonald MA, Stevenson CH, Kersten HM, Danesh-Meyer HV   +3 more
doaj   +2 more sources

Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities-an analysis of CRISPR genome-edited mouse embryos. [PDF]

Sci Rep, 2017
The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas) system is a rapid gene-targeting technology that does not require embryonic stem cells. To demonstrate dosage effects of the Pax6 gene on eye formation,
Yasue A, Kono H, Habuta M, Bando T, Sato K, Inoue J, Oyadomari S, Noji S, Tanaka E, Ohuchi H.   +9 more
europepmc   +2 more sources

Eye-head coordination abnormalities in schizophrenia.

PLoS ONE, 2013
BackgroundEye-movement abnormalities in schizophrenia are a well-established phenomenon that has been observed in many studies. In such studies, visual targets are usually presented in the center of the visual field, and the subject's head remains fixed.
Simon Schwab, Othmar Würmle, Nadja Razavi, René M Müri, Andreas Altorfer   +4 more
doaj   +5 more sources