Results 51 to 60 of about 97,046 (268)

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

Real‐World Comparison of High‐Efficacy Versus Non‐High‐Efficacy Therapies in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choice of the first disease modifying treatment (DMT) in multiple sclerosis (MS) is a topic of great interest, and whether high‐efficacy DMTs should be the first choice remains debated. We compared treatment outcomes (no evidence of disease activity [NEDA] and its components) between treatment‐naïve relapsing–remitting MS (RRMS ...
Sarmad Al‐Araji, Marcello Moccia, Alessia Bianchi, Charmaine Yam, Weaam Hamed, Suraya Mohamud, Alan J. Thompson, Frederik Barkhof, Ahmed T. Toosy, Olga Ciccarelli   +9 more
wiley   +1 more source

Changing techniques in cataract surgery: how have patients benefited?

Community Eye Health Journal, 2018
Cataract surgery is one of the most frequently performed operations in the world. Recent advances in techniques and instrumentation have resulted in earlier intervention, improved surgical outcomes, and reduced dependence on spectacles.
Aravind Haripriya, Hemant Sonawane, RD Thulasiraj   +2 more
doaj  

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Utilization of eye health‐care services in Australia: the National Eye Health Survey [PDF]

Clinical & Experimental Ophthalmology, 2017
AbstractImportanceNational data on eye health‐care service utilization will inform Australia's eye health policy.BackgroundTo investigate the utilization of eye health‐care services by Australians.DesignCross‐sectional survey.ParticipantsIndigenous Australians aged 40 years and older and non‐Indigenous Australians aged 50 years and older.MethodsOne ...
Joshua Foreman, Jing Xie, Stuart Keel, Hugh R Taylor, Mohamed Dirani   +4 more
openaire   +3 more sources

X‐Ray Computed Tomography Quantifies Primary Phases and Reveals Crack Morphology in High‐Cycle Fatigue of Aluminum Alloy EN AW‐2618A

Advanced Engineering Materials, EarlyView.
Primary phases and a fatigue crack are studied in a forged blank of an aluminum alloy using synchrotron and laboratory X‐ray computed tomography. To image the crack, the fatigue test is interrupted, and a static tensile load is applied to open the crack.
Jakob Schröder, Ying Han, Tobias Fritsch, Bardia Hejazi, Alexander Ulbricht, Birgit Skrotzki, Giovanni Bruno   +6 more
wiley   +1 more source

Postoperative cataract care: the Aravind perspective

Community Eye Health Journal, 2016
It is essential for us as eye care professionals to make the patient aware that the end of a successful cataract operation is not the end of her or his treatment for cataract.
Aravind Haripriya, Zervin R Baam, RD Ravindran   +2 more
doaj  

Utilization of eye care services among those with unilateral visual impairment in rural South India: Andhra Pradesh Eye Disease Study (APEDS)

International Journal of Ophthalmology, 2017
AIM: To report on the utilization of eye care services and its associated factors among those with unilateral visual impairment (VI) in a rural South Indian population.
Srinivas Marmamula, Giridhar Pyda, Rohit C Khanna   +2 more
doaj   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Microbubble‐Controlled Delivery of Biofilm‐Targeting Nanoparticles to Treat MRSA Infection

Advanced Functional Materials, EarlyView.
Here, an effective strategy using microbubble (MB)‐controlled delivery of biofilm‐targeting nanoparticles (BTNs) for removal and therapy of methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infections is introduced. In vivo delivery of MB with BTN is demonstrated to silence key bacterial genes involved in biofilm formation (icaA), bacterial ...
Ju Yeon Chung, Yujin Ahn, Joo Hun Lee, Seungju Yang, Seung Cheol Lee, Hyunjoon Kong, Hyun Jung Chung   +6 more
wiley   +1 more source