Results 301 to 310 of about 10,588,664 (388)

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis

Advanced Science, EarlyView.
IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
wiley   +1 more source

Exploring causal relationships between circulating micronutrients and age-related eye diseases: a Mendelian randomization study. [PDF]

Genes Nutr
Cao X, Xu Z, Zhang B, Jiang Z, Yuan X.
europepmc   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms. [PDF]

Front Pharmacol
Yan Y, Wu Y, Zhao Y, Yang Y, An G, Liu Z, Qi D.   +6 more
europepmc   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

Eye diseases in chronic kidney disease: A nationwide longitudinal case-control study in Sweden. [PDF]

Clin Exp Ophthalmol
Ballester Dolz P, Ålander K, Smedberg P, Vihlborg P, Bryngelsson IL, Westerlund J, Makdoumi K.   +6 more
europepmc   +1 more source

Horses : their feed and their feet : a manual of horse hygiene invaluable for the veteran or novice : pointing out the true source of "malaria," "disease waves," influenza, glanders, "pink-eye," etc., and how by C.E. Page ; with treatise and notes on shoeing by George Cox and M.C. Weld.

, 1883
C. E. Page, George W. Cox, Mason Cogswell Weld   +2 more
openalex   +2 more sources

Human Nervous System‐Based Biohybrid Robot‐On‐A‐Chip with Sensing Function for Toxicity Screening

Advanced Science, EarlyView.
Human nervous system‐based biohybrid robot‐on‐a chip with eye function as sensing system in addition to brain/motor neuron/muscle functions is proposed. Upon light stimulation, the eye assembloid generates electrophysiological signals, which are transmitted through the cerebral organoid and motor neuron spheroid, inducing muscle movement.
Minkyu Shin, Joungpyo Lim, Seewoo Kim, Sangeun Lee, Wei Wen Su, Jinho Yoon, Jeong‐Woo Choi   +6 more
wiley   +1 more source

A dataset of color fundus images for the detection and classification of eye diseases. [PDF]

Data Brief
Sharmin S, Rashid MR, Khatun T, Hasan MZ, Uddin MS, Marzia.   +5 more
europepmc   +1 more source

Epidemic Disease of the Eye now prevailing in Copenhagen [PDF]

NULL AUTHOR_ID
openalex   +1 more source