Results 191 to 200 of about 23,372 (299)

Effects of Dual Inhibition of VEGF‐A and Angpt‐2 on Angiogenesis and Lymphangiogenesis in an Alkali‐Induced Corneal Injury Model

open access: yesGenes to Cells, Volume 30, Issue 4, July 2025.
ABSTRACT Corneal neovascularization (CNV) is frequently observed after various corneal injuries and corneal transplantation, leading to impairment of corneal transparency. Lymphangiogenesis and the inflammatory response often accompany CNV. Chemical injury is one of the most common causes of CNV, and alkali injury has been widely used as an animal ...
Hiroshi Kuribayashi   +13 more
wiley   +1 more source

Effects of VEGFA and ANGPT2 Antibodies on the Activation of Microglia in the Early Stages of Streptozotocin‐Induced Pathogenesis of Diabetic Retinopathy

open access: yesGenes to Cells, Volume 30, Issue 4, July 2025.
ABSTRACT Diabetic retinopathy (DR) is known as a microvascular complication, in which various inflammatory symptoms, including activation of microglia, are observed. A model of hyperglycemia resembling type 1 diabetes mellitus (DM) induced in mice by intraperitoneal injection of streptozotocin (STZ) has been widely used. We examined the effects of anti‐
Toshiro Iwagawa   +6 more
wiley   +1 more source

Expanding Horizons: The First Reported Outbreak of Piscine Lactococcosis in Farmed Gilthead Seabream Sparus aurata in the Northern Tyrrhenian Sea

open access: yesJournal of Fish Diseases, Volume 48, Issue 7, July 2025.
ABSTRACT Piscine lactococcosis, caused by Lactococcus garvieae, has traditionally been reported in rainbow trout and marine fish in specific regions. However, its first outbreak in farmed gilthead seabream Sparus aurata in the northern Tyrrhenian Sea marks a significant expansion in the distribution of the disease.
Giuseppe Esposito   +11 more
wiley   +1 more source

Accumulation of Epigenetic Noise in the Aging Corneal Epithelium and Its Possible Mechanism

open access: yesThe FASEB Journal, Volume 39, Issue 11, 15 June 2025.
We found an accumulation of epigenetic noise in the aging corneal epithelium, manifested by increases and decreases in DNA methylation levels. Our findings suggest that these changes occur due to reduced activity of TET enzymes. We assume that the age‐related changes in DNA methylation patterns and the activity of TET enzymes reflect the epigenetic ...
Galina Dvoriantchikova   +2 more
wiley   +1 more source

Optic Nerve Invasion in Retinoblastoma: Impact of Eye Salvage and Adjuvant Chemotherapy. [PDF]

open access: yesInvest Ophthalmol Vis Sci
Feng ZX   +5 more
europepmc   +1 more source

Self-enucleation of the right eye by a 38-year-old woman diagnosed with schizoaffective disorder: a case report [PDF]

open access: gold, 2020
Natalia Chechko   +4 more
openalex   +1 more source

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

open access: yesAdvanced Science, Volume 12, Issue 23, June 20, 2025.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou   +7 more
wiley   +1 more source

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