Results 221 to 230 of about 23,372 (299)

The Effect of Advancing Age and Intraocular Pressure Injury on Retinal Ganglion Cell Function and Synaptic Connectivity

Aging Cell, Volume 24, Issue 6, June 2025.
The effect of advancing age and intraocular pressure injury on retinal ganglion cell function and synaptic connectivity. While young mice modulate their synaptic input to recover retinal ganglion cell function following injury, older mice compensate by altering their action potential threshold and axon initial segment (AIS) length to increase intrinsic
Vicki Chrysostomou, Sevannah Ellis, Lewis E. Fry, Robert J. Hatch, Eamonn T. Fahy, Katharina C. Bell, Ian A. Trounce, Peter van Wijngaarden, Steve Petrou, Jonathan G. Crowston   +9 more
wiley   +1 more source

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

Aging Cell, Volume 24, Issue 6, June 2025.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu, Peng Shang, Ying Xin, Emma Mahally, Mihir Nemani, Victoria Koontz, Kira Lathrop, Katarzyna M. Kedziora, Jonathan Franks, Ming Sun, Joshua W. Smith, Lauren R. DeVine, Robert N. Cole, Nadezda Stepicheva, Anastasia Strizhakova, Sreya Chattopadhyay, Stacey Hose, Jacob Samuel Zigler Jr., José‐Alain Sahel, Jiang Qian, Prasun Guha, James T. Handa, Sayan Ghosh, Debasish Sinha   +27 more
wiley   +1 more source

A case report: iridociliary melanocytoma associated with secondary glaucoma. [PDF]

Diagn Pathol
Sun Y, Chen Y, Zhu J, Guo J, Wang Z.
europepmc   +1 more source

Blockade of P2X7 receptors preserves blood retinal barrier integrity by modulating the plasmalemma vesicle‐associated protein: Implications for diabetic retinopathy

British Journal of Pharmacology, Volume 182, Issue 12, Page 2603-2620, June 2025.
Background and Purpose Plasmalemma vesicle‐associated protein (PLVAP) regulates transcytosis in vascular endothelial cells. PLVAP expression is increased in pathological conditions, such as diabetic retinopathy. P2X7 receptor antagonists have been shown to preserve blood‐retinal barrier (BRB) integrity.
Chiara Bianca Maria Platania, Francesca Lazzara, Kenneth Mitton, Naomi Haque, Wendelin Dailey, Federica Conti, Erika Giuffrida, Filippo Drago, Anca Hermenean, Cornel Balta, Hildegard Herman, Alina Ciceu, Maria Consiglia Trotta, Michele D'Amico, Giuseppe Nicosia, Settimio Rossi, Claudio Bucolo   +16 more
wiley   +1 more source

IMPLANTATION OF A GLASS BALL FOR THE SUPPORT OF AN ARTIFICIAL EYE AND MULES' OPERATION FOR THE SUBSTITUTION OF ENUCLEATION OF AN EYEBALL. [PDF]

, 1898
L. Webster Fox
openalex   +1 more source

Presumed Bilateral Ciliary Body Medulloepithelioma in a Child with Pleuropulmonary Blastoma and <i>DICER1</i> Mutation. [PDF]

Diagnostics (Basel)
Danowska M, Rogowska A, Cieślik K, Jędrzejczak-Młodziejewska J, Rakusiewicz-Krasnodębska K, Hautz W.   +5 more
europepmc   +1 more source

Consensus on the Treatment of Severe Ocular Trauma and Silicone Oil–Dependent Eyes Using Foldable Capsular Vitreous Body

Journal of Evidence-Based Medicine, Volume 18, Issue 2, June 2025.
ABSTRACT Aim To establish evidence‐based guidelines for the application of the foldable capsular vitreous body (FCVB) in managing severe ocular trauma and silicone oil–dependent eyes. Methods We conducted a comprehensive search across multiple databases, screening, extracting, and evaluating research evidence. Experts in ocular trauma and vitreoretinal
Hua Yan, Xiaofeng Lin, Wenbin Wei, Gezhi Xu, Ferenc Kuhn, Yuntao Hu, Dawei Sun, Weihong Yu, Rui Jiang, Peiquan Zhao, Yanming Huang, Jinhong Cai, Nan Wu, Zhen Chen, Jinchen Jia, Shenwen Liu, Huping Song, Jianqiao Li, Xiangyu Shi, Aijun Deng, Umit Beden, Petros Petrou, Van Overdam, Shalva Skihirtladze, Slawomir Cisiecki, Levent Karabas, Chongde Long, Lifeng Qiao, Zhenquan Zhao, Jian Ma, Sujuan Ji, Yanlai Zhang, Gongqiang Yuan, Qihua Xu, Xiangzhong Xu, Xuemin Tian, Haokun Zhang, Siyue Chen   +37 more
wiley   +1 more source

Insights into retinoblastoma pathogenesis: unraveling RB1, N-MYC and miRNA profiles. [PDF]

BMJ Open Ophthalmol
Faranoush M, Khesali F, Faranoush P, Foroughi-Gilvaee MR, Shams P, Sadighnia N, Ahmadi SAY, Fallah Azad D, Nekouian R.   +8 more
europepmc   +1 more source

Canine bilateral zygomatic sialadenitis: 20 cases (2000‐2019)

Journal of Small Animal Practice, Volume 66, Issue 6, Page 396-411, June 2025.
Objectives To describe clinical findings, cross‐sectional imaging features, management and outcome of dogs with bilateral zygomatic sialadenitis. Materials and Methods Clinical databases of three referral institutions were searched for dogs diagnosed with bilateral zygomatic sialadenitis who underwent magnetic resonance imaging or computed tomography ...
A. E. Enache, S. Maini, M. Pivetta, E. Jeanes, L. Fleming, C. Hartley, R. Tetas Pont   +6 more
wiley   +1 more source

Uveal melanoma: Updated considerations on current management modalities [PDF]

, 1995
Lee, W.R. (W.), Manschot, W.A., Strik, R. (Roel) van   +2 more
core   +1 more source