Results 131 to 140 of about 247,985 (305)

Innovative Famciclovir Eye Drop Formulations for Herpes Zoster Infections

Purpose Herpes zoster ophthalmicus, a manifestation of the varicella-zoster virus in the eye, presents significant clinical challenges. As there is no direct ocular treatment for this infection, new therapeutic options should be studied.
Alambiaga Caravaca, Adrián M., Balaguer Fernández, Cristina, Alambiaga-Caravaca, Adrián M., Balaguer-Fernández, Cristina, López-Castellano, Alicia, Domenech-Monsell, Iris M., Bernat-Just, Lucía, Domenech Monsell, Iris M., Bernat Just, Lucia, Rodilla, Vicent, López Castellano, Alicia, Merino, Virginia, Merino Sanjuán, Virginia   +12 more
core   +1 more source

Candida parapsilosis corneal graft infection from a single eye center: Histopathologic report of 2 cases

, 2015
Fungal keratitis accounts for 6–53% of all cases of ulcerative keratitis in variable studies. The majority of cases are due to septate fungi. The abnormal cornea in cases of dry eye syndrome, chronic ulceration, erythema multiform and possibly HIV ...
Al-Harby, Mosa, Maktabi, Azza, Alkatan, Hind M., Al-Rajhi, Ali A.   +3 more
core   +1 more source

Optimal Design of Novel Microemulsions-Based Two-Layered Dissolving Microneedles for Delivering Fluconazole in Treatment of Fungal Eye Infection. [PDF]

Pharmaceutics, 2022
Suriyaamporn P, Opanasopit P, Rangsimawong W, Ngawhirunpat T.   +3 more
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Eye Lesions in Patients After One Year of Kidney Transplantation

, 2023
Nguyen Le Trung,1,2 Pham Quoc Toan,3 Nguyen Kien Trung,4 Vu Anh Tuan,1 Nguyen Thu Huyen5 1Vietnam Department of Ophthalmology, Hanoi Medical University, Hanoi, Vietnam; 2Vietnam Department of Ophthalmology, Military Hospital 103, Hanoi, Vietnam; 3Vietnam
Trung NK, Trung NL, Tuan VA, Toan PQ, Huyen NT   +4 more
core  

Brain endothelial PTPRO drives LPS-induced metabolic reprogramming and neuroinflammation in sepsis-associated encephalopathy

Journal of Neuroinflammation
Background Sepsis-associated encephalopathy (SAE) is characterized by profound neuroinflammation and blood–brain barrier (BBB) disruption, yet the molecular mechanisms linking endothelial metabolic reprogramming to neuroinflammatory responses remain ...
Fengjiao Wu, Haitao Tang, Haoxuan Jia, Chang Li, Yuwei Song, Jiwei Hu, He Cao, Benben Zhang, Xiaoyu Zhang, Hairui Jiang, Zhengyan Pan, Wusheng Zhou, Zongming Gou, Tianzhen Li, Tianbao Li, Hongtao Wang, Huaxue Wang, Zhongqing Qian, Ting Wang   +18 more
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Prevalence of Antimicrobial Resistant Bacteria from Conjunctival Flora in an Eye Infection Prone Breed (Saint Bernard). [PDF]

Molecules, 2021
Nadăș GC, Novac CȘ, Matei IA, Bouari CM, Gal ZM, Tamas-Krumpe OM, Macri AM, Fiț NI.   +7 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A PTPRO-Related Five-Gene Blood Transcriptional Signature with Diagnostic Potential for Tuberculosis

Biomedicines
Background/Objectives: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major global health problem. Drug resistance and the limitations of sputum-based diagnostic methods highlight the need for additional host-response biomarkers.
Fengjiao Wu, Ru Huang, Yuxuan Lin, Xixi Zhu, Yujie Li, Huiting Dai, Xiaoyu Zhou, Fang Fang, Ying Liang, Tao Xu, Chuanwang Song, Wei Li, Xiaojing Wang, Xianyou Chang, Hongtao Wang, Ting Wang, Jingzhu Lv, Zhongqing Qian   +17 more
doaj   +1 more source