Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals [PDF]
Artificial Intelligence in the Life Sciences, 2021 Eye irritation and corrosion are fundamental considerations in developing chemicals to be used in or near the eye, from cleaning products to ophthalmic solutions.
Arthur C. Silva +8 more
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Semi-Correlations for Building Up a Simulation of Eye Irritation [PDF]
Toxics, 2023 The OECD recognizes that data on a compound’s ability to treat eye irritation are essential for the assessment of new compounds on the market. In silico models are frequently used to provide information when experimental data are lacking.
Andrey A. Toropov +3 more
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Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium [PDF]
Environmental Health and Toxicology, 2019 Disinfectants including polyhexamethylene guanidine phosphate (PHMG) and mixtures of chloromethylisothiazolinone/ methylisothiazolinone (CMIT/MIT) have been widely used in Korea to prevent microbial growth in the humidifier water, which triggered an ...
Juyoung Park, Handule Lee, Kwangsik Park
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Environmental chamber studies of eye and respiratory irritation from use of a peracetic acid–based hospital surface disinfectant [PDF]
Antimicrobial Stewardship & Healthcare Epidemiology, 2023 Objective: To characterize personal exposures and measures of eye and respiratory tract irritation in controlled environmental chamber studies of 44 healthy adult volunteers simulating upper-bound use of peracetic acid (PAA)–based surface disinfectant ...
Pamela H. Dalton +5 more
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Development of a Probability-Based In Vitro Eye Irritation Screening Platform [PDF]
BioengineeringTraditional eye irritation assessments, which rely on animal models or ex vivo tissues, face limitations due to ethical concerns, costs, and low throughput.
Seep Arora +4 more
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Eye Irritation Test of Bovis Calculus Pharmacopuncture Solutions for Eye Drop
Journal of Pharmacopuncture, 2008 Objective : This study was done to investigate the safety of Bovis Calculus pharmacopuncture solution manufactured with freezing dryness method to use eye drop.
Hyeong-sik Seo
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Jurnal Kesehatan Lingkungan, 2018 Formaldehyde is a chemical substance that has volatile and short-term effect characteristics, which can cause eye irritation. Exposure to formaldehyde in low levels can cause irritation to human eyes.
Mustika Ayu Raharyaningsih, R Azizah
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In Vivo Irritation and Sensitization Assessment of Cypermethrin, Pymetrozine, and Indoxacarb–Emamectin Benzoate Combination in Test Animals [PDF]
Journal of ToxicologyInsecticides are widely used to protect agricultural and plantation products from pests and plant-disrupting organisms. Prior to market distribution, pesticide-containing products must undergo safety evaluations, including assessments of potential skin ...
Wahyu Daradjat Natawigena +6 more
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Impedance-based in vitro eye irritation testing enables the categorization of diluted chemicals [PDF]
Scientific ReportsProducts containing chemicals with eye irritation potential need to be labeled with the respective hazard symbol. To avoid the testing of numerous dilutions of chemicals on animals, their labeling is directed by a theoretical approach.
H. Weissinger +3 more
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Laser Light-Based Opacitometer ‘Peira LLBO 180’: A new and validated opacitometer for use in the Bovine Corneal Opacity and Permeability (BCOP) eye irritation test method [PDF]
MethodsX, 2020 The “Peira LLBO 180” is a Laser Light-Based Opacitometer that can be used as an alternative for the standard OP-KIT device in the Bovine Corneal Opacity and Permeability (BCOP) test Organisation for Economic Co-operation and Development (OECD) Test ...
An R. Van Rompay +2 more
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