Results 241 to 250 of about 49,100 (276)
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Eye Irritation Response of Humans to Formaldehyde
American Industrial Hygiene Association Journal, 1983Human panelists sensitive to formaldehyde eye irritation were exposed to low concentrations of formaldehyde vapor (0.35 to 1.0 ppm) for 6 minutes. Eye irritation was evaluated by time to detection of the first trace of irritation and by subjective ranking of severity.
Joel R. Bender +3 more
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Recent Progress in the Eye Irritation Test
Toxicology and Industrial Health, 1993The rabbit eye irritation test based on the Draize method is required for the hazard assessment of chemicals and products that may come into contact with the eye. Due to the potential for the suffering of animals and subjectivity of the test, many modifications of the method have been made that involved a reduction in the number of animals and a ...
Ih Chu, Peter Toft
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The in vitro assessment of eye irritancy using isolated eyes
Food and Chemical Toxicology, 1985Rabbit eyes were removed and held in temperature-regulated chambers and irrigated with saline. A dose of 0.1 ml of test irritant was applied to each eye (six eyes per test material) and the induced change in corneal thickness measured over a 5-hour period, using a Zeiss photoslit-lamp microscope. A total of sixty materials were assessed and the results
J.B. Price, I.J. Andrews
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The Ex Vivo Eye Irritation Test as an Alternative Test Method for Serious Eye Damage/Eye Irritation
Alternatives to Laboratory Animals, 2015Ocular irritation testing is a common requirement for the classification, labelling and packaging of chemicals (substances and mixtures). The in vivo Draize rabbit eye test (OECD Test Guideline 405) is considered to be the regulatory reference method for the classification of chemicals according to their potential to induce eye injury.
Felix Spöler +4 more
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Eye irritation: an ecetoc overview
Journal of Toxicology: Cutaneous and Ocular Toxicology, 1989AbstractThe European Chemical Industry Ecology and Toxicology Center (ECETOC) has reviewed the Draize test and ways to evaluate the eye irritancy of chemicals with less reliance on animals. When animal test results are needed, ECETOC recommends that a minimum number of animals be used and that a step-wise approach be adopted, a single animal being ...
Arthur P. Walker +5 more
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Eye Irritation and Lithium Carbonate
Archives of Ophthalmology, 1980To the Editor .—Little has been mentioned in the literature discussing the effect of lithium carbonate on the eye. Makeeva et al 1 described three patients with incipient senile cataract who, after receiving lithium carbonate, showed a "sudden and acute worsening" with visual impairment.
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Eye irritancy screening for classification of chemicals
Toxicology in Vitro, 1990A screening method was applied to determine the eye irritation potential of industrial chemicals. Bovine eyes (BE) were used to predict corneal damage and chicken egg chorioallantoic membranes (CAM) to estimate the irritancy potential of chemical substances towards the conjunctivae.
Y.H.M. van Erp, P.J.J.M. Weterings
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Eye and Skin Irritation Induced by Picolines [PDF]
, 1989 Picolines (methylpyridines) are starting materials for a number of industrial and pharmaceutical products. Few toxicological studies have been carried out on these compounds. The object of the present work was to study the eye and skin irritative properties of 2-, 3- and 4-picoline in comparison with those of pyridine.
Nguyen Phu-Lich +5 more
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Ophthalmology: Gritty, irritable eyes
BMJ, 2003In the fourth part of the series, Sophia Pathai, and Andrew McNaught explain possible causes of gritty, irritable ...
Sophia Pathai, Andrew McNaught
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Evaluating the potential eye irritancy of shampoos
International Journal of Cosmetic Science, 1979SynopsisExperience in a large manufacturing unit showed that splashes of undiluted shampoo only produced transient effects in the eyes of production and packaging staff; over the same period, very few complaints of eye irritation were received from shampoo users, none of which were of a serious nature. Predictive testing is needed to make sure that new
Timothy M. Nisbet +4 more
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