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Nasal Irritation from Eye Drops [PDF]
American Journal of Rhinology, 1994 Although nasal irritation from nose drops is a common phenomenon well known to any otolaryngologist, nasal irritation from eye drops is little recognized. We describe eight patients who suffered from nasal irritation, rhinitis, and blocked nose resulting from the use of eye drops.
Tuvia Hadar, Eitan Yaniv
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The in vitro assessment of severe eye irritants
Food and Cosmetics Toxicology, 1981Abstract A method is described for the preliminary screening of new compounds for eye irritancy. Rabbit eyes were enucleated immediately after death and placed in a temperature-controlled chamber where they were superfused with saline solution. Test substances were applied to the eyes and the effects were observed with a slit-lamp biomicroscope ...
R.S. Lawrence, A.B.G. Burton, M. York
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Toxicology in Vitro, 2018
Assessment of the acute eye irritation potential is part of the international regulatory requirements for testing of chemicals. The objective of the CON4EI project was to develop tiered testing strategies for eye irritation assessment. A set of 80 reference chemicals (38 liquids and 42 solids) was tested with eight different methods.
Nathalie Alépée +9 more
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Assessment of the acute eye irritation potential is part of the international regulatory requirements for testing of chemicals. The objective of the CON4EI project was to develop tiered testing strategies for eye irritation assessment. A set of 80 reference chemicals (38 liquids and 42 solids) was tested with eight different methods.
Nathalie Alépée +9 more
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Statistical model in tests for eye irritants
Food and Chemical Toxicology, 1991A test used to classify substances for eye irritancy, as required by the Consumer Product Safety Commission, is performed on 1-3 groups of 6 albino rabbits in a sequential manner. When the statistical implications of the test are realized, it is possible for a substance to be classified as an irritant with fewer reactions than the number required for ...
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A method for the objective assessment of eye irritation
Food and Cosmetics Toxicology, 1972Abstract A method is described whereby an objective measurement of eye irritation may be made The method is based on measurement of the change in corneal thickness that follows exposure of the eye to an irritant substance and the results obtained agree well with those obtained in the subjective Draize test The proposed method has the advantage ...
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An objective method for the evaluation of eye irritation in vivo
Food and Chemical Toxicology, 1989It is generally agreed that intra- and interlaboratory variations in the evaluation of eye irritants are mainly due to the subjective judgement of eye lesions. The scoring of the palpebral conjunctivae is a typical example. To eliminate these difficulties in assessing eye irritants the relationship between corneal swelling, which can be determined ...
G.A. Jacobs, M.A. Martens
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Criteria for in vitro alternatives for the eye irritation test
Food and Chemical Toxicology, 1993A proposal encompassing considerations and criteria for the development of in vitro alternatives to the eye irritation test has been developed and is presented here. Two factors need to be considered initially in developing an alternative test. The first is to determine whether the alternative assay is to be used as a screen or as a replacement for the
N.L. Wilcox +13 more
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In vitro predictive tests for eye irritants
Toxicology in Vitro, 1990The developments and attitudes towards in vitro testing since the first major workshop on irritation testing five years ago (Reinhardt et al., 1985) are summarized. Many test systems have been described and an increasing number of compounds tested. However, the in vivo data basis used for comparison is still heterogeneous and a proper analysis of most ...
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