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Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing

Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing
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CON4EI: EpiOcular eye irritation test (EIT)

Toxicology Letters, 2016
Assessment of the acute eye irritation potential is part of the international regulatory requirements for testing of chemicals. The objective of the CON4EI project was to develop tiered testing strategies for eye irritation assessment. A set of 80 reference chemicals (38 liquids and 42 solids) was tested with eight different methods.
H. Kandarova, A.R. Van Rompay, E. Adriaens, N. Alépée, A. Drzewiecka, P. Fochtman, K. Gruszka, R. Guest, G. Maglennon, J. Schofield, J.A. Willoughby, S. Verstraelen   +11 more
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Scoring for eye irritation tests

Food and Chemical Toxicology, 1993
Scoring of the rabbit eye test and the resulting evaluation and classification should provide useful information about the likelihood that a test material may cause injury on contact with the human eye. When an animal test is necessary, a rabbit eye test based on the following characteristics is proposed for deriving the maximum information from the ...
W.A. Chambers, S. Green, K.C. Gupta, R.N. Hill, K. Huntley, P.M. Hurley, L.A. Lambert, C.C. Lee, J.K. Lee, P.T. Liu, D.K. Lowther, C.D. Roberts, V.M. Seabaugh, J.A. Springer, N.L. Wilcox   +14 more
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The Ex Vivo Eye Irritation Test as an Alternative Test Method for Serious Eye Damage/Eye Irritation

Alternatives to Laboratory Animals, 2015
Ocular irritation testing is a common requirement for the classification, labelling and packaging of chemicals (substances and mixtures). The in vivo Draize rabbit eye test (OECD Test Guideline 405) is considered to be the regulatory reference method for the classification of chemicals according to their potential to induce eye injury.
Felix, Spöler, Oya, Kray, Stefan, Kray, Claudia, Panfil, Norbert F, Schrage   +4 more
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Recent Progress in the Eye Irritation Test

Toxicology and Industrial Health, 1993
The rabbit eye irritation test based on the Draize method is required for the hazard assessment of chemicals and products that may come into contact with the eye. Due to the potential for the suffering of animals and subjectivity of the test, many modifications of the method have been made that involved a reduction in the number of animals and a ...
I H, Chu, P, Toft
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Refinement of the Slug Mucosal Irritation test as an alternative screening test for eye irritation

Toxicology in Vitro, 2005
The objective of this study was to limit the test procedure time of the Slug Mucosal Irritation test to one day and to determine whether it is a relevant and reliable method to predict the eye irritation potential of chemicals. The irritation potential of several eye reference chemicals can be estimated by the amount of mucus produced when tested at a ...
E, Adriaens, M M M, Dhondt, J P, Remon
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Statistical model in tests for eye irritants

Food and Chemical Toxicology, 1991
A test used to classify substances for eye irritancy, as required by the Consumer Product Safety Commission, is performed on 1-3 groups of 6 albino rabbits in a sequential manner. When the statistical implications of the test are realized, it is possible for a substance to be classified as an irritant with fewer reactions than the number required for ...
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In vitro predictive tests for eye irritants

Toxicology in Vitro, 1990
The developments and attitudes towards in vitro testing since the first major workshop on irritation testing five years ago (Reinhardt et al., 1985) are summarized. Many test systems have been described and an increasing number of compounds tested. However, the in vivo data basis used for comparison is still heterogeneous and a proper analysis of most ...
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Vitrigel-Eye Irritancy Test Method Using HCE-T Cells

Toxicological Sciences, 2013
We previously reported that the time-dependent relative changes of transepithelial electrical resistance (TEER) after exposing four different chemicals to a human corneal epithelium (HCE) model were well correlated to the potential of ocular irritancy.
Hiroyuki, Yamaguchi, Hajime, Kojima, Toshiaki, Takezawa   +2 more
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Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing

Alternatives to Laboratory Animals, 2019
Collagen vitrigel membranes (CVMs) comprising high-density collagen fibrils equivalent to in vivo connective tissues have been widely used in cell culture applications. A human corneal epithelium (hCE) model was previously developed by the Takezawa group, by culturing HCE-T cells (derived from hCE cells) on a CVM scaffold in a chamber that provided an
Hajime, Kojima, Hiroyuki, Yamaguchi, Takashi, Sozu, Nicole, Kleinstreuer, Lim, Chae-Hyung, Wannhsin, Chen, Mika, Watanabe, Takayuki, Fukuda, Kunihiko, Yamashita, Toshiaki, Takezawa   +9 more
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