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Criteria for in vitro alternatives for the eye irritation test
Food and Chemical Toxicology, 1993A proposal encompassing considerations and criteria for the development of in vitro alternatives to the eye irritation test has been developed and is presented here. Two factors need to be considered initially in developing an alternative test. The first is to determine whether the alternative assay is to be used as a screen or as a replacement for the
S. Green +13 more
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Alternative Methods for Eye and Skin Irritation Tests: An Overview
Journal of Pharmaceutical Sciences, 2008The evaluation of eye and skin irritation potential is essential to ensuring the safety of individuals in contact with a wide variety of substances designed for industrial, pharmaceutical or cosmetic use. The Draize rabbit eye and skin irritancy tests have been used for 60 years to attempt to predict the human ocular and dermal irritation of such ...
M P, Vinardell, M, Mitjans
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Eye Irritation Testing: Historical Perspectives and Future Directionsâ€
Journal of Toxicology: Cutaneous and Ocular Toxicology, 1986AbstractChemical effects on the eye have been a subject of scientific investigation for over 150 years. The development of current testing protocols is traced from early clinical observations through animal models to present efforts to produce in vitro model systems capable of predicting effects on specific eye tissues.
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[In vitro alternatives to Draize eye irritation test].
Wei sheng yan jiu = Journal of hygiene research, 2006For reasons of animal welfare and better science, a series of in vitro methods, including assays based isolated eye or cornea, Chorioallantoic membrane, cultured tissue or cell, had been established and evaluated to replace the Draize eye irritation test.
Jianchang, Zhou +3 more
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Ophthalmologic Perspectives on Eye Irritation Testing
Journal of Toxicology: Cutaneous and Ocular Toxicology, 1998B. Nussenblatt Robert +6 more
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Genetics, genomics, and cancer risk assessment
Ca-A Cancer Journal for Clinicians, 2011Kenneth Offit
exaly

