Results 51 to 60 of about 2,554,674 (292)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

Eye Movement Disorders and the Cerebellum.

open access: yesJournal of clinical neurophysiology, 2019
The cerebellum works as a network hub for optimizing eye movements through its mutual connections with the brainstem and beyond. Here, we review three key areas in the cerebellum that are related to the control of eye movements: (1) the flocculus ...
A. Shemesh, D. Zee
semanticscholar   +1 more source

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan   +46 more
wiley   +1 more source

Microsaccades in applied environments: Real-world applications of fixational eye movement measurements

open access: yesJournal of Eye Movement Research, 2020
Across a wide variety of research environments, the recording of microsaccades and other fixational eye movements has provided insight and solutions into practical problems.
Robert G Alexander   +2 more
doaj   +1 more source

Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan   +12 more
wiley   +1 more source

Eye movement analysis of children’s attention for midline diastema

open access: yesScientific Reports, 2022
No previous studies have investigated eye-movement patterns to show children’s information processing while viewing clinical images. Therefore, this study aimed to explore children and their educators’ perception of a midline diastema by applying eye ...
Vanessa Y. Cho   +5 more
doaj   +1 more source

Characteristics of Cerebral Palsy in the Midwestern US

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim   +6 more
wiley   +1 more source

Study of an Extensive Set of Eye Movement Features: Extraction Methods and Statistical Analysis

open access: yesJournal of Eye Movement Research, 2018
This work presents a study of an extensive set of 101 categories of eye movement features from three types of eye movement events: fixations, saccades, and post-saccadic oscillations.
Ioannis Rigas   +2 more
semanticscholar   +1 more source

Altered Dynamic Functional Network Connectivity in Post‐Stroke Aphasia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Previous studies examining post‐stroke aphasia (PSA) patients via resting‐state functional magnetic resonance imaging (rs‐fMRI) have predominantly focused on static functional connectivity. In contrast, the current investigation aims to elucidate the alterations in dynamic functional network connectivity (dFNC) among PSA patients ...
Guihua Xu   +6 more
wiley   +1 more source

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