Results 81 to 90 of about 2,266,049 (248)

Targeting Macrophage STING O‐GlcNAcylation via Small‐Molecule Allosteric Modulation for Psoriasis Therapy

Advanced Science, EarlyView.
Paeoniflorin allosterically targets the STING cyclic dinucleotide‐binding domain, stabilizes an inactive open conformation, and disrupts STING–OGT interaction to reduce Thr229 O‐GlcNAcylation and downstream signaling. This mechanism restrains myeloid STING activation, alleviates psoriasis‐like inflammation, and is supported by analyses of patient ...
Fang‐Fang Zhuo, Cheng‐Chen Hou, Wei Wang, Ya‐Xuan Zhu, Ling Li, Li‐Juan Liu, Chuan‐Jian Lu, Peng‐Fei Tu, Yang Liu, Rui‐Zhi Zhao, Ke‐Wu Zeng   +10 more
wiley   +1 more source

Dual U-Net with multi-task attention for automated eyelid curvature quantification

Frontiers in Medicine
ObjectiveEyelid curvature analysis serves as a key morphological indicator in the diagnosis of ophthalmic diseases and postoperative evaluation. This study aims to develop an automated and reproducible image processing method to accurately extract eyelid
Jimei Wu, Yang Yang, Cheng Wan, Cheng Wan, Meina Yang, Weihua Yang, Wei Chi   +6 more
doaj   +1 more source

Kaposi’s sarcoma with the eyelid involvement (6 clinical cases)

Alʹmanah Kliničeskoj Mediciny, 2018
Kaposi's sarcoma is a multifocal tumor from vascular endothelium with a low grade of malignancy. It develops due to underlying immune deficiency and is associated with human herpesvirus 8. Kaposi's sarcoma of the eyelids is rare, and its diagnosis can be
E. E. Grishina
doaj   +1 more source

AI‐Powered Smart Displays and AR Glasses: Perspectives and Challenges

Advanced Intelligent Systems, EarlyView.
This perspective examines how AI is reshaping smart displays and AR glasses. The latest in image‐quality enhancement, sensor‐integrated display optimization, and physiological sensing in display systems, followed by AI‐assisted AR technologies including waveguide optimization, image compensation, foveated rendering, and multimodal sensing, is discussed.
Luke Benoit, Yizhou Qian, Yi‐Chien Chen, Ziyang Shen, Po‐Sheng Chiu, Youngeon Lee, Cheng‐Han Ke, Chih‐Lung Lin, Shin‐Tson Wu   +8 more
wiley   +1 more source

Eyelid-openness and mouth curvature influence perceived intelligence beyond attractiveness [PDF]

, 2016
Impression formation is profoundly influenced by facial attractiveness, but the existence of facial cues which affect judgments beyond such an ‘attractiveness halo’ may be underestimated. Since depression and tiredness adversely affect cognitive capacity,
Talamas, Sean N., Perrett, David I., Perrett, DI, Talamas, SN, Talamas, Sean, Axelsson, John, Mavor, Kenneth Ian, Axelsson, J,, Sundelin, Tina,, Sundelin, Tina, Perrett, David Ian, Mavor, KI, Mavor, Kenneth I., Sundelin, T,, Perrett, David Ian; id_orcid, Mavor, Kenneth Ian; id_orcid   +15 more
core   +1 more source

Biallelic PAX6 Variants in an Adult With Severe Microphthalmia and Preserved Intellectual Function

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT PAX6 encodes a dosage‐sensitive transcription factor that is essential for eye development. Heterozygous PAX6 disease is well characterized, but biallelic disease is extremely rare and has been associated with anophthalmia, severe brain malformations, and perinatal lethality.
Karl De Geer, Britt‐Marie Anderlid, Lena Jacobson, Daniel Martín Muñoz, Erik Björck   +4 more
wiley   +1 more source

A Novel Homozygous Nonsense Variant in DCHS1 in a Brazilian Patient With Van Maldergem Syndrome Type 1: Clinical Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Van Maldergem syndrome (VMLDS) is an ultra‐rare autosomal recessive disorder characterized by craniofacial dysmorphism, intellectual disability, hypotonia, skeletal anomalies, and feeding difficulties. It is caused by biallelic variants in DCHS1 or FAT4 genes.
Gabriela Roldão Correia‐Costa, Bruna Fagundes Rodrigues Alaite, Vera Lúcia Gil‐da‐Silva‐Lopes, Carlos Eduardo Steiner, Társis Paiva Vieira   +4 more
wiley   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Floppy Eyelid Syndrome: pathogenesis, diagnosis, treatment [PDF]

Клиническая офтальмология
T.N. Yurieva1–3, D.Yu. Samsonov1, A.Yu. Buglanov4 1Irkutsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Irkutsk,   Russian Federation 2Irkutsk State Medical Academy of Professional Education — Branch of the ...
T.N. Yur’eva, D.Yu. Samsonov, A.Yu. Buglanov   +2 more
doaj  

Elastohydrodynamics of the eyelid wiper

, 2008
This paper presents an elastohydrodynamic model of the human eyelid wiper. Standard lubrication theory is applied to the fluid layer between the eyelid wiper and ocular surface.
Jones, M.B., Jones, Malcolm B., McElwain, Sean, McElwain, DL, Collins, MJ, Collins, Michael J., Fulford, G.R., Fulford, Glenn, Fulford, GR, Collins, M.J., Jones, MB, Please, C.P., McElwain, D.L.S., Please, Colin P., Please, Colin   +14 more
core   +1 more source