FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang+14 more
wiley +1 more source
A casemix analysis of hospital admissions in six specialties for Barking & Havering Health Authority. [PDF]
To examine admission rates for Barking & Havering residents to six surgical specialties by first looking at elective, emergency and total workloads, then at the casemix of elective work using Healthcare Resource Groups.
Cook, Adam+2 more
core
Role of microsatellite instability, immunohistochemistry and Mismatch Repair germline aberrations in immunosuppressed transplant patients: a phenocopy dilemma in Muir-Torre Syndrome. [PDF]
Sebaceous tumours and keratoacanthomas are uncommon neoplasms that constitute important clinical criteria for Muir-Torre Syndrome (MTS) diagnosis. In MTS patients, the increased risk of developing synchronous or metachronous visceral malignancies is ...
Manfredini, Marco+3 more
core +1 more source
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie+21 more
wiley +1 more source
Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface
Drop‐on‐demand printing is used to replicate the spatial compartmentalization of the breast cancer‐host interface. Hydrogel confinement affects phenotypic changes in cells at the spheroid interface that drives a two‐fold increase in chemotherapeutic resistance compared to control unconfined spheroids.
Bram G. Soliman+4 more
wiley +1 more source
Transposition flap for reconstruction of lower eyelid wounds adjacent to the tarsus after Mohs micrographic surgery: a case series [PDF]
Skin cancers affecting the eyelid can be a reconstructive challenge due to the complexity of the local anatomy. In addition to precise eradication of the tumor, maximal preservation of the skin is essential for both functional and cosmetic outcomes ...
Bruna Cabral Meira Chaves+2 more
doaj +1 more source
Recurrent atypical fibroxanthoma of the limbus [PDF]
Author version made available in accordance with the publisher's policy.We report an unusual presentation of recurrent atypical fibroxanthoma of the limbus.
Brennan, Catriona+3 more
core +1 more source
ABSTRACT Objective There is limited consensus on endoscopic skull base surgery (ESBS) reconstruction principles. This study aims to generate comprehensive themes regarding ESBS reconstruction by pooling the experiences of ESBS experts, with comparison to a literature review of current published evidence.
Edward C. Kuan+77 more
wiley +1 more source
Periorbital syringomas - excision with Castroviejo scissors: experience in 38 patients and literature review [PDF]
BACKGROUND: Syringomas are benign adnexal tumors from intraepidermal eccrine ducts, treated by diverse surgical modalities with variable results. OBJECTIVES: 1.
Bagatin, Edileia+2 more
core +3 more sources
Assessment of Anticancer Effects of Aloe vera on 3D Liver Tumor Spheroids in a Microfluidic Platform
The comparative effects of Doxorubicin and Aloe vera on HepG2 spheroids grown in a microfluidic device are illustrated in the graphical abstract. In the upper panel, red markers indicate that Doxorubicin treatment primarily induces necrosis in the spheroids.
Atakan Tevlek+2 more
wiley +1 more source