Results 261 to 270 of about 112,908 (344)

Synthesis and Biological Characterization of 4,4‐Difluoro‐3‐(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D4R) Antagonist in vitro Tool compounds

ChemMedChem, EarlyView.
The work presents details of the efforts to design and characterize novel D4 inhibitors. A new 4,4‐difluoropiperidine ether series that confers improved potency and selectivity for D4 versus the other dopamine receptor subtypes is identified. Extensive structure‐activity relationship around this privileged group identifies the key structural changes to
Saeedeh Saeedi, Sumaiya Nahid, Anish K. Vadukoot, Corey R. Hopkins   +3 more
wiley   +1 more source

Frontal Eye Field in the Precentral Sulcus: A Direct Electrical Cortical Stimulation Study With Stereo-EEG Electrodes. [PDF]

Brain Behav
Jin Y, Li K, Liu X, Zhang F, Wang X, Fei L, Tan Q, Li D, Wang X, Wang G, Chen J, Hu X.   +11 more
europepmc   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

From Erysipelas to Epiglottitis: Managing Complications in Invasive Group A Streptococcal Infection. [PDF]

Am J Case Rep
Matsumoto S, Masuda T, Minemura N, Nakajima H, Tatsuno K.   +4 more
europepmc   +1 more source

Laboratory‐Based Time‐Resolved In Situ X‐Ray Absorption Spectroscopy for Tracking Transformations of Working Electrocatalysts

Chemistry–Methods, EarlyView.
The experimental setup presented in this work combining laboratory‐based X‐ray absorption spectroscopy with an electrochemical reactor advances the fundamental understanding of electrocatalysts at extended time scales. By the example of the electrochemical reduction of CO2, the parameters are discussed that are relevant for optimizing the system to ...
Martina Rüscher, Joon Baek Jang, Andrea Martini, Petrik Bischoff, Wiebke Frandsen, Janis Timoshenko, Beatriz Roldan Cuenya   +6 more
wiley   +1 more source

A novel assistant-free technique for ptosis surgery: Combining small fish hook retractors and frilled drapes. [PDF]

JPRAS Open
Kakudo N, Matsuoka Y, Kushida S, Hihara M.   +3 more
europepmc   +1 more source

Periorbital Necrotizing Fasciitis: Presentation to management. [PDF]

JPRAS Open
Mégevand V, Martineau J, Baccaro M, Farhoumand PD, Kalbermatten DF, André-Lévigne D.   +5 more
europepmc   +1 more source

Treatment of the Induration of the Soft Tissue of the Lower Eyelids After Accidental Oil Injections. [PDF]

Plast Reconstr Surg Glob Open
Safronov V.
europepmc   +1 more source

Milium of the Nipple: Report of Two Cases. [PDF]

Clin Cosmet Investig Dermatol
Shen Y, Bian K, Hua Y, Song X.
europepmc   +1 more source

The uninvited guest: Phthiriasis palpebrarum.

Trop Parasitol
Gayathri J, Rajalakshmi AR, Valentina Y.
europepmc   +1 more source