Results 101 to 110 of about 173,176 (244)

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Sobre a construção de habitus e disposições: o domínio da fruição musical [PDF]

, 2015
O texto discute problemas levantados em torno do conceito de habitus, cujo potencial explicativo parece passar pelo aprofundamento de questões relativas à construção, atualização e gestão das disposições.
Campos, Luís Melo
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Cinema e televisão: uma fusão desigual [PDF]

, 2016
Entre a Televisão e o Cinema… as relações são complexas e desiguais. A TV tem sido sempre considerada o «parente pobre». Porque é um media de massas dirigido a audiências muito vastas e indiferenciadas; porque parece gratuita… é da ordem da Aparição ...
Maia e Carmo, Teresa
core  

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

A persistência do carisma

Mediações: Revista de Ciências Sociais, 2010
Resenha: TEIXEIRA, Rosana da Câmara Krig-ha, bandolo! Cuidado, aí vem Raul Seixas. Rio de Janeiro: 7Letras/FAPERJ, 2008.
Marco Antonio Perruso
doaj  

A Novel Pixel-Based Reconfigurable Antenna Applied in Fluid Antenna Systems With High Switching Speed

IEEE Open Journal of Antennas and Propagation
Fluid Antenna Systems (FASs) have recently been proposed for enhancing the performance of wireless communication. FAS have previously exploited mechanical movement or liquids to perform the required adaptation to the wireless environment.
Jichen Zhang, Junhui Rao, Zan Li, Zhaoyang Ming, Chi-Yuk Chiu, Kai-Kit Wong, Kin-Fai Tong, Ross Murch   +7 more
doaj   +1 more source

Participação e sustentabilidade na comunicação estratégica e organizacional [PDF]

, 2014
Coleção Relações públicas e comunicação organizacional (vol. 2); Série: Comunicação estratégicaNas últimas décadas as organizações têm vindo a enfrentar desafios comunicacionais decorrentes da evolução do contexto social, económico e político em que se
Melo, Ana Guilhermina Seixas Duarte
core  

Heterogeneous Wettability‐Based Construction of Two‐Phase Interfaces for Underwater Reversible Adhesion

Advanced Science, EarlyView.
The design employs heterogeneous wettability surfaces that construct stable oil‐water interfaces to achieve robust and rapid reversible adhesion. Linear enhancement of adhesion strength is realized through multi‐interface patterning. This adhesive enables rapid on‐demand detachment within five seconds via voltage‐induced electrolysis, offering a level ...
Xiaokai Li, Yonghui Zhang, Yongxin Li, Jiahao Zhang, Yuheng Li, Zhengyu Li, Jianwu Wang, Yaochen Lv, Yanan Wang, Jiyu Liu, Xin Liu, Huanxi Zheng   +11 more
wiley   +1 more source