Results 101 to 110 of about 158,736 (197)

Reconsidering the impact of saturated fat intake on metabolic health: A critical review of evidence and controversies

Food Biomacromolecules, EarlyView.
Abstract Saturated fats (SFAs) play a complex role in health; therefore, their intake has been a topic of debate in the field of nutrition science. Therefore, this article emphasizes the importance of a balanced diet rather than SFA, considering genetic and metabolic differences, and advocates for the reconsideration of dietary guidelines based on the ...
Akash Kumar, Dipak S. Thorat, Sangeeta Yadav, Pooja Yadav, Jhilam Pramanik, Yogesh V. Ushir, Sudarshan Singh, Bhupendra G. Prajapati   +7 more
wiley   +1 more source

LXRα and PPARα Mediated Hepatic Lipid Metabolic Disruption Induced by the UV Filter EHMC in 2D and 3D HepaRG Cell Models

Food Safety and Health, EarlyView.
Dietary UV filter EHMC induces hepatic steatosis in HepaRG cells at noncytotoxic concentrations. Mechanistically, EHMC binds nuclear receptors (LXRα, PPARα), upregulating SREBP‐1 to accelerate fatty acid synthesis. These findings highlight the potential metabolic toxicity of widespread EHMC exposure through food sources.
Shanglin Yang, Na Li, Yingnan Han, Mei Ma   +3 more
wiley   +1 more source

Simultaneous ultrasound and needle electromyography recording of fasciculations in amyotrophic lateral sclerosis. [PDF]

Clin Neurophysiol Pract
Sugimoto T, Tachiyama K, Hironaka A, Naito H, Nakamori M, Aoki S, Yamazaki Y, Maruyama H.   +7 more
europepmc   +1 more source

UK participation in the UK National External Quality Assessment Scheme for mismatch repair immunohistochemistry: insights from the last decade. [PDF]

J Clin Pathol
Farmkiss LA, Dodson A, Parry S, James MC, Frayling IM, Arends MJ.   +5 more
europepmc   +1 more source

Keratin 18 functions as a lactyltransferase to trigger necroptosis in diabetic kidney disease by modulating Fas transcription. [PDF]

Exp Mol Med
Zhao Q, Liu X, Yang Y, Meng F, Meng Z, Zhu M.   +5 more
europepmc   +1 more source

Efficacy and related factors of levonorgestrel‐releasing intrauterine system combined with metformin in fertility‐preserving treatment for atypical endometrial hyperplasia and early endometrial cancer: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To compare the efficacy of the levonorgestrel‐releasing intrauterine system combined with metformin versus oral progestin combined with metformin in fertility‐preserving treatment for patients with atypical endometrial hyperplasia and early endometrial cancer, and to analyze related factors affecting efficacy.
Pengpeng Gu, Jialu Gao, Yuxin Li, Mei Huang, Xiaoshuang Wang, Xin Zhao   +5 more
wiley   +1 more source

Effect of Early Administration of Casirivimab and Imdevimab in Hospitalized Patients with COVID-19: A Post Hoc Analysis. [PDF]

Infect Drug Resist
Mylonakis E, Sullivan A, Somersan-Karakaya S, You X, Lyu J, Shehadeh F, Geba GP.   +6 more
europepmc   +1 more source

Advances in Immunological Combination Therapy for Colorectal Cancer

iMetaMed, EarlyView.
Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu, Rongbo Wen, Tianshuai Zhang, Fuao Cao, Xiaoming Zhu, Liqiang Hao, Wei Zhang, Guanyu Yu   +7 more
wiley   +1 more source

Cytoskeletal Regulation of Podosome-Focal Adhesion Balance in GM-CSF- and Flt3L-Derived Dendritic Cells. [PDF]

Cells
Biernacka Z, Gregorczyk-Zboroch K, Lasocka I, Bartak M, Gieryńska M, Struzik J, Toka FN, Szulc-Dąbrowska L.   +7 more
europepmc   +1 more source

Single‐cell profiling of peripheral blood reveals acute‐phase immune dysregulation in human scrub typhus

iMeta, EarlyView.
Integrated single‐cell RNA sequencing, spectral flow cytometry, immune‐receptor repertoire profiling, and plasma proteomics revealed coordinated peripheral immune remodeling during acute scrub typhus. Patients exhibited expansion of cytotoxic, clonally amplified CD8+ T cells with exhaustion‐associated features, depletion and apoptosis of CD4+ T cells ...
Yijia Guo, Yi Niu, Nihui Zhang, Xiao Han, Liyuan Zhang, Yongguo Du, Lifen Han, Xiuying Tian, Zhao Xu, Gaoyu Wang, Kwok‐Yung Yuen, Jasper Fuk‐Woo Chan, Dahua Xu, Feifei Yin   +13 more
wiley   +1 more source