Results 271 to 280 of about 301,916 (339)

Bilateral Osteonecrosis of the Femoral Head and Proximal Femur After Corticosteroid Injections: A Case Report. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Hiredesai AN, Holle AM, Van Schuyver PR, Deckey DG, Probst NE, Spangehl MJ.   +5 more
europepmc   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

Consequences of Dietary Manganese Deficiency or Mn₂O₃ Nanoparticles Supplementation on Rat Manganese Biodistribution and Femur Morphology. [PDF]

Nutrients
Cholewińska E, Dworzański W, Juśkiewicz J, Listos P, Ognik K.   +4 more
europepmc   +1 more source

NO‐Driven Janus Nanomotor Enhances T‐Cell Infiltration by Reconstructing Tumor‐Associated Blood and Lymphatic Vessels

Advanced Science, EarlyView.
NO‐driven hollow gold Janus nanomotors (HAM) are engineered to improve tumor blood vessel normalization throughout the entire tumor region to enhance T‐cell intratumoral infiltration, and generate and capture whole‐tumor antigens as an in situ cancer vaccine to enhance T‐cell activation, therefore enhancing the antitumor immune response.
Qingping Ma, Shunli Fu, Yiming Xia, Shuying Gao, Zhenxing Xia, Panpan Gu, Shijun Yuan, Jinhu Liu, Shuang Liang, Nan Li, Qinglin Yang, Weiwei Mu, Jie Liu, Xinrui Liu, Yongjun Liu, Na Zhang   +15 more
wiley   +1 more source

Mechanical Stimulation in the Residual Femur During Gait in Transfemoral Prosthesis Users Provides a Potential Reason for Bone Mineral Density Loss. [PDF]

Int J Numer Method Biomed Eng
Zavaleta-Ruiz JL, Fatone S, Major MJ, Pankaj P.   +3 more
europepmc   +1 more source

Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial‐Neural Axis

Advanced Science, EarlyView.
The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang, Di Mu, Su Liu, Peng‐Bo Jing, Bin Wu, Xiao‐Mei Yang, Jia‐Yi Ge, Qing‐Yi Li, Hao‐Hao Chen, Feng‐Ming Zhang, Bing Wang, Ying‐Ying Zhang, Linnan Qian, Zi‐Yi Zhu, Yu‐Sen Ou, Shi‐Yu Sun, Lin Luo, Yu Feng, Changyu Jiang, Zhuo Sun, Yong Chen, Hai‐Li Pan, Bin Wang, Fen‐Fei Gao, Jie Wu, Zhigang Lu, Tong Liu, Yan‐Gang Sun, Xing‐Jun Liu   +28 more
wiley   +1 more source

Effect of Different Footwear on the Knee Joint: Biomechanical Analysis and Acute T2 Relaxation Time Changes After Walking in Minimalistic and Neutral Footwear. [PDF]

Orthop J Sports Med
Malus J, Casula V, Urbaczka J, Vilimek D, Nieminen M, Hamill J, Horka V, Rygelova M, Uchytil J.   +8 more
europepmc   +1 more source

Mild Photothermal Bimetallic Mesoporous Nanozyme Triggers Immunogenic Cell Death and Immune Contexture Remodeling for Precision Hepatocellular Carcinoma Treatment

Advanced Science, EarlyView.
In this study, a Pt/Co BNzyme with peroxidase/GPx‐like activity is developed, increasing oxidative stress by generating ROS and depleting GSH to induce ICD. The mild PTT effect enhanced its enzymatic activity. The Pt/Co BNzyme remodeled the TME, promoting DC maturation.
Yanbing Huang, Lei Ding, Yanbing Cao, Qiang Feng, Yanjuan Li, Jianmin Wang, Zhixiong Cai, Fuli Xin, Peiyuan Wang, Jingfeng Liu   +9 more
wiley   +1 more source

Functional Outcome of Distal Femur Nail Multilocking (DFN-ML) in Distal Third Femur Fractures. [PDF]

Cureus
Bisht M, Peshin C, Kumar S.
europepmc   +1 more source

Bimetallic Nanozyme Amplifier for Synergistic Ferroptosis‐Cuproptosis and Metabolic Reprogramming to Reshape Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
The Bimetallic Nanozyme Amplifier (PEG@AuCZ@CC) to maximize hydrogen peroxide production and reprogram tumor metabolism from glycolysis to oxidative phosphorylation. This shift enhances ferroptotic/cuproptotic signaling cascades and creates a glucose‐enriched but lactate‐depleted tumor microenvironment (TME), effectively overcoming immune tolerance in ...
Jianzhang Luo, Kunzhao Huang, Xiaoyuan Yi, Pei Lu, Huaying Xie, Wen Li, Qingyu Zeng, Feifei He, Duo Wang, Liyan Wang   +9 more
wiley   +1 more source