Results 111 to 120 of about 16,694 (193)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Förster Resonance Energy Transfer (FRET) Demonstrates In Vitro Chitosan-Coated Nanocapsules Suitability for Intranasal Brain Delivery. [PDF]

ACS Appl Mater Interfaces
Alleva M, Baranyai Z, Esteban-Pérez N, Martínez-Vicente P, Martín-Rapún R, Moros M, Martínez de la Fuente J.   +6 more
europepmc   +1 more source

A Protocol for Using Förster Resonance Energy Transfer (FRET)-force Biosensors to Measure Mechanical Forces across the Nuclear LINC Complex. [PDF]

J Vis Exp, 2017
Arsenovic PT, Bathula K, Conway DE.
europepmc   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

A Förster Resonance Energy Transfer (FRET)-Based Immune Assay for the Detection of Microcystin-LR in Drinking Water. [PDF]

Sensors (Basel)
Capo A, Pennacchio A, Montagnese C, Hadjiantonis A, Demosthenous P, Giusti A, Staiano M, D'Auria S, Varriale A.   +8 more
europepmc   +1 more source

Brief encounters and lasting impressions—How target protein half‐life affects reactive metabolite signaling

The FEBS Journal, EarlyView.
Lipid‐derived reactive electrophile molecules (REMs) are generated from fatty acids through lipoxygenase or cyclooxygenase‐assisted catalysis, or free radical‐induced lipid peroxidation events. REMs so‐produced covalently modify nearby protein‐cysteines, and in the case of ‘first responder’ proteins, can trigger gain‐of‐function signaling with context ...
Marcus J. C. Long, Lorna Birkby, Yimon Aye   +2 more
wiley   +1 more source

CdSe/ZnS Quantum Rods (QRs) and Phenyl Boronic Acid BODIPY as Efficient Förster Resonance Energy Transfer (FRET) Donor-Acceptor Pair. [PDF]

Nanomaterials (Basel)
Salerno G, Palladino P, Marelli M, Polito L, Minunni M, Berti D, Scarano S, Biagiotti G, Richichi B.   +8 more
europepmc   +1 more source

Probing the Ion Binding Site in a DNA Holliday Junction Using Förster Resonance Energy Transfer (FRET). [PDF]

Int J Mol Sci, 2016
Litke JL, Li Y, Nocka LM, Mukerji I.
europepmc   +1 more source

Structural and functional insights into rhodopsin‐like and secretin‐like GPCR–arrestin interactions and regulation

The FEBS Journal, EarlyView.
Distinct GPCR phosphorylation barcodes and arrestin conformational states direct arrestin‐mediated signaling and trafficking. The graphical abstract depicts the structural diversity of GPCR–arrestin complexes by overlaying representative core‐engaged and tail‐engaged conformations.
Varsha Gupta, Annette G. Beck‐Sickinger   +1 more
wiley   +1 more source

From productive coupling to catalytic commitment: An evolutionarily tuned interdomain connector in Leishmania Aha1 orchestrates Hsp90 activation

The FEBS Journal, EarlyView.
LbAha1 activates LbHsp90 through a multistep mechanism in which productive N‐domain docking precedes ATP‐driven rearrangement and linker ordering. The LbAha1 linker transitions from a flexible to helical state, stabilizing an asymmetric, catalytically competent closed complex.
Paulo Roberto Dores‐Silva, Thiago Vargas Seraphim, Karine Minari, Izabella Rodrigues Fonseca da Silva, Winston Pinheiro Claro Gomes, Leijiane Figueira de Sousa, Arthur Moraes Franco da Rocha, Leandro Ramos Souza Barbosa, Jeremiah Stanson Joseph, Júlio César Borges   +9 more
wiley   +1 more source