Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7 [PDF]
Nature Communications, 2019 The Bin/Amphiphysin/Rvs167 (BAR) domain superfamily, which includes FCH-BAR (F-BAR) domain proteins are membrane-sculpting proteins. Here the authors combine a range of techniques and show that the F-BAR domain of growth-arrest specific protein 7 (GAS7 ...
Kyoko Hanawa-Suetsugu +19 more
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Membrane sculpting by F-BAR domains studied by molecular dynamics simulations. [PDF]
PLoS Computational Biology, 2013 Interplay between cellular membranes and their peripheral proteins drives many processes in eukaryotic cells. Proteins of the Bin/Amphiphysin/Rvs (BAR) domain family, in particular, play a role in cellular morphogenesis, for example curving planar ...
Hang Yu, Klaus Schulten
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Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation [PDF]
Cell Reports, 2015 F-BAR domain proteins regulate and sense membrane curvature by interacting with negatively charged phospholipids and assembling into higher-order scaffolds. However, regulatory mechanisms controlling these interactions are poorly understood.
Charlotte F. Kelley +12 more
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Comparative Study of Curvature Sensing Mediated by F-BAR and an Intrinsically Disordered Region of FBP17 [PDF]
iScience, 2020 Summary: Membrane curvature has emerged as an intriguing physical principle underlying biological signaling and membrane trafficking. The CIP4/FBP17/Toca-1 F-BAR subfamily is unique in the BAR family because its structurally folded F-BAR domain does not ...
Maohan Su +6 more
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The F-BAR Domain of Rga7 Relies on a Cooperative Mechanism of Membrane Binding with a Partner Protein during Fission Yeast Cytokinesis [PDF]
Cell Reports, 2019 Summary: F-BAR proteins bind the plasma membrane (PM) to scaffold and organize the actin cytoskeleton. To understand how F-BAR proteins achieve their PM association, we studied the localization of a Schizosaccharomyces pombe F-BAR protein Rga7, which ...
Yajun Liu +4 more
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Modulation of fungal virulence through CRZ1 regulated F-BAR-dependent actin remodeling and endocytosis in chickpea infecting phytopathogen Ascochyta rabiei. [PDF]
PLoS Genetics, 2021 Polarized hyphal growth of filamentous pathogenic fungi is an essential event for host penetration and colonization. The long-range early endosomal trafficking during hyphal growth is crucial for nutrient uptake, sensing of host-specific cues, and ...
Manisha Sinha +6 more
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RNAi Screen in Tribolium Reveals Involvement of F-BAR Proteins in Myoblast Fusion and Visceral Muscle Morphogenesis in Insects [PDF]
G3: Genes, Genomes, Genetics, 2019 In a large-scale RNAi screen in Tribolium castaneum for genes with knock-down phenotypes in the larval somatic musculature, one recurring phenotype was the appearance of larval muscle fibers that were significantly thinner than those in control animals ...
Dorothea Schultheis +2 more
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Phase separation drives cortical enrichment of the F-BAR proteins Rga7 and Rga8 to maintain cell integrity [PDF]
Cellular and Molecular Life SciencesPolarized cell growth necessitates the dynamic remodeling of the plasma membrane, a process requiring BAR domain-containing proteins. While classical BAR proteins, with their crescent-shaped structure, are well characterized, the mechanisms underlying ...
Biyu Zheng +11 more
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Opposing functions of F-BAR proteins in neuronal membrane protrusion, tubule formation, and neurite outgrowth [PDF]
Life Science Alliance, 2019 Neurite formation is a fundamental antecedent to axon and dendrite formation, but the mechanisms that underlie this important process are poorly characterized. Here, we demonstrate that two F-BAR proteins, CIP4 and FBP17, have opposing functions in early
Kendra L Taylor +7 more
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The Tubulation Activity of a Fission Yeast F-BAR Protein Is Dispensable for Its Function in Cytokinesis [PDF]
Cell Reports, 2016 F-BAR proteins link cellular membranes to the actin cytoskeleton in many biological processes. Here we investigated the function of the Schizosaccharomyces pombe Imp2 F-BAR domain in cytokinesis and find that it is critical for Imp2’s role in contractile
Nathan A. McDonald +6 more
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