Results 31 to 40 of about 32,136 (210)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

On the locally functionally countable subalgebra of C(X) on locally functionally countable subalgebra of C(X)

Applied General Topology, 2015
Let $C_c(X)=\{f\in C(X) : |f(X)|\leq \aleph_0\}$, $C^F(X)=\{f\in C(X): |f(X)|
O. A. S. Karamzadeh, M. Namdari, S. Soltanpour   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A Pair of Generalized (α, α)-Derivations With Identities Related to Prime Ideals

Journal of Mathematics
Let A be an arbitrary ring, α an automorphism of A, I a nonzero ideal of A, and ϒ a prime ideal of A satisfying the condition ϒ⊊αI. This research investigates the interplay between two generalized α,α-derivations, Ω and G (associated with α,α-derivations
Ali Yahya Hummdi, Hafedh Alnoghashi, Radwan Mohammed Al-Omary, Abdelkarim Boua   +3 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Generalized Derivations of Prime Rings

International Journal of Mathematics and Mathematical Sciences, 2007
Let R be an associative prime ring, U a Lie ideal such that u2∈U for all u∈U. An additive function F:R→R is called a generalized derivation if there exists a derivation d:R→R such that F(xy)=F(x)y+xd(y) holds for all x,y∈R. In this paper, we prove that
Huang Shuliang
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

MDS Symbol-Pair Repeated-Root Constacylic Codes of Prime Power Lengths Over $\mathbb F_{p^m}+ u \mathbb F_{p^m}$

IEEE Access, 2019
MDS codes have the highest possible error-detecting and error-correcting capability among codes of given length and size. Let p be any prime, and s, m be positive integers.
H. Q. Dinh, P. Kumam, P. Kumar, S. Satpati, A. K. Singh, W. Yamaka   +5 more
doaj   +1 more source