Results 91 to 100 of about 12,914,892 (258)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

F-score vs. z-score cutoff.

, 2012
F-score versus z-score cutoff for prediction of coregulated gene pairs and TRIs are plotted in blue and red respectively. Also, the F-score curves for the prediction of coregulated gene pairs in coexpression gene pairs with at least one TF gene is ...
Edward Ott (180528), Geet Duggal (180521), Yuan Li (67017), Michelle Girvan (180524), Wai Lim Ku (180517)   +4 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Use of the SARC-F Score as an Aid in Fragility Fractures Prevention. [PDF]

Rev Bras Ortop (Sao Paulo), 2023
Martini CAN, Weigert CS, Stiegemaier ACB, Ferreira APRB, Gonçalves EL, Valle SF.   +5 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Saltimbanco. Vocal score

, 2012
1 vocal score (233 p.) ; 27 x 36 cm. Riduzione con accomp. di pianoforte.
Pacini, Giovanni (1796 - 1867)
core  

Combined fibrinogen concentration and neutrophil-to-lymphocyte ratio, an integrative model of the inflammatory response and coagulation cascades, for predicting prognosis in patients with upper tract urothelial carcinoma

Biomolecules & Biomedicine
Inflammation and coagulation cascades are closely correlated with cancer occurrence and progression. This study investigated the prognostic value of the combination of plasma fibrinogen level and neutrophil-to-lymphocyte ratio (F-NLR) in patients with ...
Yangqing Zheng, Chen Chen, Chaoyue Lu, Yongxing Bao, Weishi Zhang, Haote Liang, Tingyu Ye, Zhixian Yu, Yeping Li, Lina Zhou, Deguan Yu, Binwei Lin   +11 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Adaptive Experimental Design Using the Propensity Score [PDF]

Many social experiments are run in multiple waves, or are replications of earlier social experiments. In principle, the sampling design can be modified in later stages or replications to allow for more efficient estimation of causal effects.
Keisuke Hirano, Jinyong Hahn, Dean Karlan   +2 more
core   +2 more sources

Novel Adaption of the SARC-F Score to Classify Pediatric Hemato-Oncology Patients with Functional Sarcopenia. [PDF]

Cancers (Basel), 2023
Verwaaijen EJ, van der Torre P, Vormoor J, Pieters R, Fiocco M, Hartman A, van den Heuvel-Eibrink MM.   +6 more
europepmc   +1 more source