Toric Methods in F-Theory Model Building
We discuss recent constructions of global F-theory GUT models and explain how to make use of toric geometry to do calculations within this framework. After introducing the basic properties of global F-theory GUTs, we give a self-contained review of toric
Johanna Knapp, Maximilian Kreuzer
doaj +1 more source
F-Theories with Reduced Monodromy and Effective String Theories [PDF]
We discuss aspects of the non-standard version of F-theory based on the arithmetic of torsion points on elliptic curves.
arxiv
Kleinschmidt's 'The Formenkreis Theory' The Formenkreis Theory and the Progress of the Organic World. A Re-Casting of the Theory of Descent and Race-Study to Prepare the Way for a Harmonious Conception of the Universal Reality O. Kleinschmidt F. C. R. Jourdain [PDF]
W. S.
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Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi+26 more
wiley +1 more source
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé+7 more
wiley +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak+14 more
wiley +1 more source
Discussion: “Economic Life of Equipment: Derivation of Formulas for the Selection and Replacement of Manufacturing Equipment Which Depend Upon the Theory of Economic Utilization of Capital Resources” (Vorlander, H. O., and Raymond, F. E., 1932, Trans. ASME, 54(10), pp. 29–50) [PDF]
Harold V. Coes
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This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini+10 more
wiley +1 more source
Rheology: Theory and Applications. Volume 1. edited by F. R. Eirich [PDF]
A. J. C. Wilson
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There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes+20 more
wiley +1 more source