A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Compatibility of the evolution equation for heat flux in dual-phase-lag and three-phase-lag with the principles of thermodynamics. [PDF]
Fawzy A, Mahmoud W, Rawy EK, Ghaleb AF.
europepmc +1 more source
Horizon thermodynamics in \begin{document}${f(R,R^{\mu\nu}R_{\mu\nu}})$\end{document} theory
Haiyuan Feng, Rong-Jia Yang
openalex +1 more source
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Exploring the implementation and theory of a school-based diet and active lifestyle intervention among primary school children. [PDF]
Chan CMJ +4 more
europepmc +1 more source
A nonlinear Calderón-Zygmund $ L^2$-theory for the Dirichlet problem involving $ -|Du|^γΔ^N_p u=f$ [PDF]
Qianyun Miao, Fa Peng, Yuan Zhou
openalex +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
A Systematic Review and Meta-Analysis of Physical Activity Interventions in Colorectal Cancer Survivors: An Evidence Evaluation Attempt Across Racial/Ethnic Groups. [PDF]
Mbous YPV +3 more
europepmc +1 more source
The
Thomas W. Grimm
openalex +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source

