Results 101 to 110 of about 362,830 (157)

Clinical Characteristics and Outcomes of Bloodstream Infections Caused by Metallo-β-Lactamase-Producing Enterobacterales in Argentina: A Subanalysis of the EMBARCAR Prospective Multicenter Cohort Study. [PDF]

Open Forum Infect Dis
Cordova E, Balbuena JP, Mykietiuk A, Farina J, Gañete M, Scapellato P, Lespada MI, Nannini E, Contreras R, Cunto E, Barcelona L, Pasteran F, Salgueira C, Hojman M, Blanco M, Lopez Alegre H, Cox Fernandez WE, Ezcurra C, Godoy D, Biglia MA, Lopez Furst MJ, Mendez G, Aguirre Rios MF, Altclas J, Sanchez C, Stryjewski ME.   +25 more
europepmc   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Food sources of macro- and micronutrients in young children and adults following vegan, vegetarian, and omnivorous diets. [PDF]

Eur J Nutr
Tilli V, Hovinen T, Kettunen E, Freese R, Itkonen ST, Erkkola M, Suomalainen A, Korkalo L.   +7 more
europepmc   +1 more source

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, EarlyView.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source

Interpretable machine learning model based on routine metabolic laboratory indices to identify advanced chronic kidney disease. [PDF]

Front Endocrinol (Lausanne)
Ye B, Zhang X, Zhu W, Xiao Z, Huang S.
europepmc   +1 more source

Fabrication of High‐Density Multimodal Neural Probes Based on Heterogeneously Integrated CMOS

Advanced Science, EarlyView.
A chiplet‐based methodology democratizes active neural probe development on standard bulk CMOS services. This yields the first probe combining high‐density electrophysiology (416 electrodes) with calcium imaging (832 photodiodes) and complete on‐chip signal processing across 13 shanks.
Ju Hee Mun, Miji Kim, Wooyeon Shin, Yongjun Park, Kanghwan Kim, Il‐Joo Cho, Jae Won Shim, Min Soo Kim, Sunwoo Lee, Jeongjin Kim, Changhyuk Lee   +10 more
wiley   +1 more source

Impact of deep learning image reconstruction on ADC quantification and histogram metrics: a phantom study. [PDF]

Eur Radiol Exp
Marzi S, Bruzzaniti V, Laganaro F, Di Giulio G, Farella M, Tonnetti A, Terrenato I, Castellana R, Vidiri A.   +8 more
europepmc   +1 more source

MGDP: Mastering a Generalized Depth Perception Model for Quadruped Locomotion

Advanced Science, EarlyView.
ABSTRACT Perception‐based Deep Reinforcement Learning (DRL) controllers demonstrate impressive performance on challenging terrains. However, existing controllers still face core limitations, struggling to achieve both terrain generality and platform transferability, and are constrained by high computational overhead and sensitivity to sensor noise.
Yinzhao Dong, Ji Ma, Yidan Lu, Jiahui Zhang, Wanyue Li, Yeke Chen, Teng Zhang, Xuechao Chen, Zhangguo Yu, Peng Lu   +9 more
wiley   +1 more source

Kidney Outcomes in ANCA-Glomerulonephritis According to Induction Immunosuppression and Histopathology. [PDF]

Kidney Int Rep
Uzzo M, Mescia F, Scott J, O'Brien J, Galesic K, Genovesi S, Trivioli G, Allinovi M, Gunnarsson I, Juto A, Hall R, Bajema I, Brix SR, L'Imperio V, Kronbichler A, Bruchfeld A, La Manna G, Cozzolino M, Sinico RA, Crnogorac M, McAdoo SP, Little MA, Jayne D, Alberici F, European Vasculitis Society.   +24 more
europepmc   +1 more source