Machine stability and dosimetry for ultra‐high dose rate FLASH radiotherapy human clinical protocol
Abstract Background The FLASH effect, induced by ultra‐high dose rate (UHDR) irradiations, offers the potential to spare normal tissue while effectively treating tumors. It is important to achieve precise and accurate dose delivery and to establish reliable detector systems, particularly for clinical trials needed to help the clinical transfer of FLASH‐
Patrik Gonçalves Jorge+9 more
wiley +1 more source
Stochastic resonance of a nanomagnet excited by spin transfer torque
Spin transfer torque from spin-polarized electrical current can excite large-amplitude magnetization dynamics in metallic ferromagnets of nanoscale dimensions.
Boone, Carl T.+3 more
core +1 more source
Design Considerations for Large Detector Arrays on Submillimeter-wave Telescopes [PDF]
The emerging technology of large (~ 10,000 pixel) submillimeter-wave bolometer arrays presents a novel optical design problem---how can such arrays be fed by diffraction-limited telescope optics where the primary mirror is less than 100,000 wavelengths ...
Stark, Antony A.
core +4 more sources
Developing reference plans for evaluating global clinical trials credentialing and PSQA systems
Abstract Purpose To develop a practical framework for creating a diverse set of validated reference plans (varying in complexity) and implement a workflow to introduce beam modeling, calibration, and delivery errors into the reference cohort to test and compare various dosimetry audit methodologies.
Fre'Etta M. D. Brooks+13 more
wiley +1 more source
An Adaptation of the Hoshen-Kopelman Cluster Counting Algorithm for Honeycomb Networks [PDF]
We develop a simplified implementation of the Hoshen-Kopelman cluster counting algorithm adapted for honeycomb networks. In our implementation of the algorithm we assume that all nodes in the network are occupied and links between nodes can be intact or
Popova, Hristina
core
Impact of respiratory motion on dose distribution in SIB‐SBRT for lung cancer
Abstract Purpose Respiratory motion is a major source of dose uncertainty in lung cancer radiotherapy. The dose distribution of simultaneous integrated boost‐stereotactic body radiotherapy (SIB‐SBRT) is inhomogeneous and is significantly impacted by respiratory motion for lung cancer. The effect of respiratory motion on SIB‐SBRT was investigated with a
Lingling Liu+7 more
wiley +1 more source
Clinical Trial Readiness in Limb Girdle Muscular Dystrophy R1 (LGMDR1): A GRASP Consortium Study
ABSTRACT Objective Identifying functional measures that are both valid and reliable in the limb girdle muscular dystrophy (LGMD) population is critical for quantifying the level of functional impairment related to disease progression in order to establish clinical trial readiness in the context of anticipated therapeutic trials.
Stephanie M. Hunn+29 more
wiley +1 more source
Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden+15 more
wiley +1 more source
Dielectric breakdown in spin polarized Mott insulator
Nonlinear response of a Mott insulator to external electric field, corresponding to dielectric breakdown phenomenon, is studied within of a one-dimensional half-filled Hubbard model.
A. A. Ovchinnikov+4 more
core +1 more source
The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type
ABSTRACT Objective Determine the association between diabetes and metabolic syndrome (MetS) burden (number of MetS criteria fulfilled) and pain, neuropathy severity, and fiber type involvement in individuals with established polyneuropathy. Methods The Peripheral Neuropathy Research Registry was queried for individuals with type 1 and type 2 diabetes ...
Long Davalos+13 more
wiley +1 more source