Results 101 to 110 of about 1,169,291 (287)

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Phylogenetic Group Determination of Escherichia coli Isolated from Animals Samples

The Scientific World Journal, 2015
This study analyzes the occurrence and distribution of phylogenetic groups of 391 strains of Escherichia coli isolated from poultry, cattle, and water buffalo. The frequency of the phylogroups was A = 19%, B1 = 57%, B2 = 2.3%, C = 4.6%, D = 2.8%, E = 11%,
Fernanda Morcatti Coura, Soraia de Araújo Diniz, Marcos Xavier Silva, Jamili Maria Suhet Mussi, Silvia Minharro Barbosa, Andrey Pereira Lage, Marcos Bryan Heinemann   +6 more
doaj   +1 more source

Steady-State Hadronic Gamma-Ray Emission from 100-Myr-Old Fermi Bubbles

, 2014
The Fermi Bubbles are enigmatic \gamma-ray features of the Galactic bulge. Both putative activity (within $\sim$ few $\times$ Myr) connected to the Galactic center super-massive black hole and, alternatively, nuclear star formation have been claimed as ...
Bicknell, Geoffrey V., Carretti, Ettore, Crocker, Roland M., Hill, Alex S., Sutherland, Ralph S.   +4 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

СИНТЕЗ ПРОСТАГЛАНДИНОВ F И I РЯДА3. СИНТЕЗ 3-ЭНДО-ГИДРОКСИ-2-ЭКЗО-[(E)-3-ОКСООКТ-1-ЕНИЛ]-6-ОКСАБИЦИКЛО[3.3.O]ОКТАН-7-ОНА ЧЕРЕЗ ЭТИЛЕНОВЫЙ КЕТАЛЬ 2,3-ЭНДО- ЭПОКСИБИЦИКЛ О[3.2.O]ГЕПТАН-6-ОНА [PDF]

, 1988
L Lahe, Ü Lille, M Lopp, A Pals, O Parve   +4 more
openalex   +1 more source

Superconductivity in novel BiS2-based layered superconductor LaO1-xFxBiS2

, 2012
Layered superconductors have provided some interesting fields in condensed matter physics owing to the low dimensionality of their electronic states. For example, the high-Tc (high transition temperature) cuprates and the Fe-based superconductors possess
Bednorz J. G., Chen X. H., Ekimov E. A., Guo J., Hsu F. C., Ito T., Izumi F., Kamihara Y., Kawaji H., Maeda H., Mizuguchi Y., Momma K., Ren Z. A., Rotter M., Schilling A., Takano Y., Tanryverdiev V. S., Wang X. C., Werthamer N. R., Wu M. K., Yamanaka S., Yeh K. W.   +21 more
core   +1 more source

Hydroxychloroquine Associated With Lower Glomerular Filtration Rate Decline in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long‐term benefits of HCQ on kidney function preservation is critical.
Shivani Garg, Brad Rovin, Brad C. Astor, Tripti Singh, Fauzia Hollnagel, Megan Kuik, Lexie Kolton, Callie Saric, S. Sam Lim, Christie M. Bartels   +9 more
wiley   +1 more source

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source