Results 201 to 210 of about 1,347,746 (312)

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

Automated RECIST tumor response classification through prompt-guided large language models. [PDF]

Sci Rep
Mergen M, Busch F, Sauter AP, Pfeiffer D, Makowski MR, Spitzl D, Gassert FT.   +6 more
europepmc   +1 more source

Impact of Evaluation Protocols on F1-Score and AVPR in Anomaly Detection Benchmarks

Anomaly detection is a widely explored domain in machine learning. Many models are proposed in the literature, and compared through different metrics measured on various datasets. The most popular metrics used to compare performances are F1-score, AUC and AVPR. In this paper, we show that F1-score and AVPR are highly sensitive to the contamination rate.
openaire   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Correction: Prediction of the ectasia screening index from raw Casia2 volume data for keratoconus identification by using convolutional neural networks. [PDF]

PLoS One
Mirsalehi M, Fassbind B, Streich A, Langenbucher A.   +3 more
europepmc   +1 more source

Llama3 and Codestral F1-Score Degradation Under Synthetic Code Obfuscation

This report synthesises findings from 1 peer-reviewed paper addressing the following research question: How does the F1-score of Llama3 and Codestral degrade when classifying vulnerabilities in Big-Vul samples subjected to varying levels of synthetic obfuscation compared to clean code.
openaire   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

HPA-UNet-LSNet: An LSNet-based U-Net with hybrid pooling attention for accurate segmentation of Haloxylon ammodendron crowns from UAV RGB imagery. [PDF]

PLoS One
Li D, Yang X, Li Y, Liang T.
europepmc   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Machine Learning Approaches to Early Detection of Parkinson's Disease Using Speech Analysis Technique. [PDF]

Neurol Int
Hossain MA, Traini E, Amenta F.
europepmc   +1 more source