Results 271 to 280 of about 3,188,697 (327)

Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The flowchart of this research. Abstract Background Dry eye disease (DED) predominantly results from elevated tear film osmolarity, which can not only cause ocular inconvenience but may lead to visual impairments, severely compromising patient well‐being and exerting substantial economic burdens as well.
Ziyu Liu   +9 more
wiley   +1 more source

A new CRISPR‐mediated Apc knockout allele leads to pyloric gland adenoma‐like gastric polyps in mice with C57BL/6;FVB/N mixed background

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The exon 16 of the mouse Apc gene was targeted with CRISPR/Cas9 system and a novel Apc knockout mouse model was generated by creating a frameshift mutation at codon 750 (ApcΔ750). The polyp number, polyp distribution and the overall survival of mice carrying the ApcΔ750 allele significantly differs between the F8‐FVB‐ApcΔ750 and F4‐B6;FVB‐ApcΔ750 mouse
Sarp Uzun   +7 more
wiley   +1 more source

A comparative evaluation of the enhanced PLS‐Tree algorithm with multiple latent score vectors

open access: yesJournal of Advanced Manufacturing and Processing, EarlyView.
Abstract Multicollinearity and heterogeneity are prevalent challenges in the analysis of process industry datasets, necessitating algorithms capable of addressing both simultaneously. The partial least squares (PLS)‐Tree algorithm, which integrates PLS regression with decision tree methodologies, stands out by concurrently addressing data heterogeneity
Shyam Panjwani   +3 more
wiley   +1 more source

Validating the Accuracy of Parkinson's Disease Clinical Diagnosis: A UK Brain Bank Case–Control Study

open access: yesAnnals of Neurology, EarlyView.
Objective Despite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post‐mortem examination as the gold standard for diagnosis. Seminal clinicopathological series highlighted that a relevant number of patients alive‐diagnosed with idiopathic PD have an alternative post ...
Lazzaro di Biase   +2 more
wiley   +1 more source

Presenting a prediction model for HELLP syndrome through data mining. [PDF]

open access: yesBMC Med Inform Decis Mak
Farajollahi B   +3 more
europepmc   +1 more source

Flavonoid‐Derived Probes for the Detection of Islet Amyloid Polypeptide Aggregates

open access: yesAnalysis &Sensing, EarlyView.
Misfolding and aggregation of islet amyloid polypeptide (IAPP) has been implicated in Type‐2 diabetes (T2D), contributing to β‐cell dysfunction. We developed flavonoid‐based probes, F4 and MF1, for detecting IAPP fibrils. These probes showed improved fluorescence response, over 10‐fold higher binding affinity than Thioflavin T and enabled specific ...
Zijie Luo   +6 more
wiley   +1 more source

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