Results 191 to 200 of about 128,249 (242)

Engineered Bacillus subtilis regulates intestinal barrier in ETEC K88‐infected piglets and modulates miR‐1250‐5p/NFκB pathway in IPEC‐J2

open access: yesiMetaOmics, EarlyView.
Upon enterotoxigenic Escherichia coli (ETEC) K88 infection, intestinal barrier function is disrupted with compromised tight junctions, accompanied by an exacerbated inflammatory response, proliferation of pathogenic Escherichia, and depletion of beneficial Lactobacillus paralimentarius.
Chaoyue Wen   +11 more
wiley   +1 more source

Decidual macrophage‐mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion

open access: yesiMeta, EarlyView.
Decidual macrophages from recurrent spontaneous abortion (RSA) patients promote trophoblast ferroptosis and impair trophoblast cell function. Mechanistically, the CXCL2/NF‐κB/HMOX1 axis mediates this effect. Conversely, trophoblasts co‐cultured with RSA decidual macrophages induce pro‐inflammatory macrophage polarization through IL‐6/JAK2/STAT3 ...
Xin Chen   +9 more
wiley   +1 more source

Black phosphorus‐based photothermal disruption of cancer‐associated fibroblast barriers and tumor‐associated macrophage targeting to enhance anti‐PD‐L1 immunotherapy in triple‐negative breast cancer

open access: yesInterdisciplinary Medicine, EarlyView.
MBB modulates the TNBC tumor microenvironment by targeting TAM/CXCL1 and facilitates anti‐PD‐L1 therapy by disrupting CAF barriers via its photothermal effect. This combined strategy subsequently enhances the efficacy of PD‐L1 mAb and suppresses TNBC progression, metastasis, and recurrence.
Bo Pan   +12 more
wiley   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

open access: yesInterdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong   +15 more
wiley   +1 more source

Chemically Defined Medium Enables GDNF-Driven Early Neuronal-like Phenotype of Human Dental Pulp Stem Cells. [PDF]

open access: yesCells
Silva-Lucero MD   +12 more
europepmc   +1 more source

Effect of Zinc Oxide Nanoparticles From Infant Formula Milk Powder on Colon Cells In Vitro

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Zinc is an essential trace element that participates in numerous metabolic processes; however, excessive exposure may interfere with the absorption of other metals, such as copper. In recent years, nanotechnology has experienced rapid growth, and zinc oxide nanoparticles (ZnO NPs) have garnered significant attention due to their versatile ...
Gloria Salinas‐Lucero   +2 more
wiley   +1 more source

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