Results 21 to 30 of about 58,318 (219)

Polyfluoralkylierte zellpenetrierende Peptid‐Additive verbessern die intrazelluläre Proteinaufnahme durch eine anhaltende und monomere Lipidinteraktion

open access: yesAngewandte Chemie, EarlyView.
Wir berichten, dass nicht‐zytotoxische, polyfluoralkylierte zellpenetrierende Peptide (CPPs) als CPP‐Additive die intrazelluläre Proteinaufnahme signifikant verbessern, indem sie die Membranverweildauer der CPP‐Additive erhöhen. Durch die Kombination von biophysikalischen Experimenten und Molekulardynamiksimulationen zeigen wir zudem, dass die ...
Sarah Hansen   +10 more
wiley   +1 more source

Polyfluoroalkyl‐Tagged Cell‐Penetrating Peptide‐Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction

open access: yesAngewandte Chemie International Edition, EarlyView.
We introduce cell‐penetrating peptides (CPPs) with polyfluoroalkyl‐tags that drastically enhance intracellular protein delivery by promoting membrane retention. Via the combination of live‐cell imaging, biophysical analysis, and computational simulations, we reveal how fluorous CPPs interact with membranes via monomeric interactions and dynamic tag ...
Sarah Hansen   +10 more
wiley   +1 more source

Food export restrictions during the COVID-19 pandemic: Real and potential effects on food security

open access: yesInternational Journal of Management and Economics, 2022
The purpose of the article is to review and critique the implementation of food export restrictions in times of crisis in addressing food security challenges.
Kowalska Aleksandra   +2 more
doaj   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova   +9 more
wiley   +1 more source

A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically complex. This study presents a modular mechanistic model of the IVT process to advance scientific understanding ...
Keqi Wang   +12 more
wiley   +1 more source

Development of Trade Relations of Bosnia and Hercegovina with Slovenia: Different Aspects and Characteristics

open access: yesNaše Gospodarstvo, 2019
The paper is aimed at identifying characteristics of trade relations of Bosnia and Herzegovina (BiH) with the Republic of Slovenia (Slovenia) in order to contribute to determining the position of BiH in its bilateral trade. The foreign trade analysis has
Brkić Snježana
doaj   +1 more source

Labor standards and social conditions in free trade zones: the case of the Manaus free trade zone

open access: yesEconomics: Journal Articles, 2020
The creation of the Manaus Free Trade Zone had a development purpose in the Brazilian political, economic and social scenario between 1960 and 1970. This industrial pole was an important device in achieving the desired development, populating a region ...
Teixeira Louisiana Cavalcanti
doaj   +1 more source

Improving Antioxidants and Physicochemical Properties of Wild Rice Noodles by Fortification With Carrot Powder

open access: yesCereal Chemistry, EarlyView.
ABSTRACT Background and Objectives Wild rice (WR), a nutritious cereal rich in phytochemicals, remains underutilized despite its health benefits. This study explored deep purple (DP), purple sun hybrid (PSH), purple haze (PH), cosmic purple (CP), and vistaric sky blue (VSB) carrot powders as fortificants in WR noodles at 10%, 20%, and 30% levels in ...
Beverly Cheruto Too   +3 more
wiley   +1 more source

Capture of adeno‐associated viruses from clarified lysate by continuous flow ultracentrifugation: a comparative study of iodixanol and sucrose gradients

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Adeno‐Associated Virus vectors are widely used in gene therapy due to their safety and efficacy. Despite the interest in their therapeutical application, AAV purification remains a significant challenge. Density gradient ultracentrifugation using cesium chloride, sucrose, or iodixanol gradients are common methods for AAV ...
Sabrina Leigheb   +6 more
wiley   +1 more source

Quality of Family Life and Workplace Deviant Behaviour with Perceived Competence as a Mediator among University Staff

open access: yesNaše Gospodarstvo, 2020
Several studies have found a variety of factors as antecedents of deviant behaviour but the role of family life on workplace deviant behaviour, as well as the mediating role of perceived competence in the quality of family life-deviant behaviour ...
Fagbenro Dare A., Olasupo Mathew O.
doaj   +1 more source

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