Results 81 to 90 of about 74,932 (226)
Adjustment for Inconsistency in Adaptive Phase 2/3 Designs With Dose Optimization
Pharmaceutical Statistics, Volume 24, Issue 6, November/December 2025.ABSTRACT Adaptive Phase 2/3 designs hold great promise in contemporary oncology drug development, especially when limited data from Phase 1 dose‐finding is insufficient for identifying an optimal dose. However, inconsistent results between Phase 2 and Phase 3 may raise regulatory and practical concerns.
Cong Chen, Mo Huang, Xuekui Zhang
wiley +1 more source
Volumes of Polytopes Without Triangulations
, 2017 The geometry of the dual amplituhedron is generally described in reference to a particular triangulation. A given triangulation manifests only certain aspects of the underlying space while obscuring others, therefore understanding this geometry without ...
Enciso, Michael
core +1 more source
Financial Review, Volume 60, Issue 4, Page 1389-1414, November 2025.ABSTRACT We introduce a novel framework that dynamically optimizes currency factor strategies via trading currency spot and forward. We examine the performance of 24,336 portfolio optimization approaches and find that the optimized currency factors significantly outperform the naïve factors after correcting for data snooping bias.
Minyou Fan +3 more
wiley +1 more source
Achieving Portfolio Diversification through Cryptocurrencies in European Markets
Business Systems Research, 2019 Background: Cryptocurrencies represent a specific technological innovation in financial markets that keeps getting more and more popular among investors around the world. Given the specific characteristics of the cryptocurrencies, this paper examines the
Pavković Ana +2 more
doaj +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 7, Page 135-146, October 2025.ABSTRACT The missense SNP NC_000004.12:g.102267552C>T (also known as SLC39A8.p.(Ala391Thr), rs13107325) in SLC39A8 encodes a zinc transporter. This SNP has been linked to schizophrenia and is the likely causal variant for one of the genome‐wide association loci associated with the disorder. Using regression analyses, we tested whether the schizophrenia‐
Sophie E. Smart +12 more
wiley +1 more source
Global financial cycles and exchange rate forecast: A factor analysis
Borsa Istanbul Review, 2020 This study applies portfolio balance theory in forecasting exchange rate. The study further argues for the need to account for the role of Global Financial Cycle (GFCy).
Ibrahim D. Raheem
doaj +1 more source
Is $Z_c(3900)$ a molecular state
, 2013 Assuming the newly observed $Z_c(3900)$ to be a molecular state of $D\bar D^*(D^{*} \bar D)$, we calculate the partial widths of $Z_c(3900)\to J/\psi+\pi;\; \psi'+\pi;\; \eta_c+\rho$ and $D\bar D^*$ within the light front model (LFM).
Ke, Hong-Wei +2 more
core +1 more source
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract INTRODUCTION The ε4 allele of the apolipoprotein E (APOE) gene is a risk factor for the development of Alzheimer's disease (AD). APOE4 isoform is associated with increased white matter lesions in humans. To identify the underlying mechanisms of white matter impairment associated with APOE4, we investigated the effects of APOE4 and APOE3 on ...
Md Mamun Al‐Amin +9 more
wiley +1 more source
On Kernel Formulas and Dispersionless Hirota Equations
, 2006 We rederive dispersionless Hirota equations of the dispersionless Toda hierarchy from the method of kernel formula provided by Carroll and Kodama. We then apply the method to derive dispersionless Hirota equations of the extended dispersionless BKP(EdBKP)
Braden H. W. +3 more
core +1 more source
Neonatal Procedural Pain Disrupts Phosphorylation of KCC2 in the Spinal Cord
Developmental Neurobiology, Volume 85, Issue 4, October 2025.ABSTRACT Neonatal procedural pain experienced in the neonatal intensive care unit can lead to long‐lasting remodeling of the central nervous system and, in particular, of the spinal nociceptive network. Preclinical studies indicate a disrupted inhibitory versus excitatory balance in the spinal cord due to reduced γ‐aminobutyric acid (GABA) ergic ...
Mathilde Baudat +4 more
wiley +1 more source