Results 171 to 180 of about 185,022 (244)

Multiscale Modeling of an 8-Week Combination Regimen of Bemnifosbuvir and Ruzasvir in Patients with Chronic Hepatitis C Virus Infection. [PDF]

Clin Pharmacol Ther
Zitzmann C, Ribeiro RM, Marc A, Zhou XJ, Perelson AS.   +4 more
europepmc   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Prognostic value of liver histology in steatotic liver disease: a systematic literature review and meta-analysis. [PDF]

J Comp Eff Res
Barritt AS, Qasim A, Kim Y, Miller SD, O'Donnell J, Johnston K.   +5 more
europepmc   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Regression-Associated Macrophages Recruit Natural Killer Cells That Constrain Targeted Therapy Resistance. [PDF]

Cancer Res
Hsu CH, Chen J, Donahue LR, Lee KJ, Chang YW, Lin J, Kacaj D, White RM, Weiss RS, Zhang ZY, White AC.   +10 more
europepmc   +1 more source

F4 [PDF]

Arthropod Management Tests, 2012
Eric T. Natwick, Martin I. Lopez
openaire   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

Correction for Zamorano-Dominguez et al., Systemic <i>Kras</i> ablation disrupts myeloid cell homeostasis in adult mice. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Boosting the Dopant Accommodation in Charge-Transfer Supramolecular Electrets Using Carbohydrate Block Copolymers in Phototransistor Memory. [PDF]

ACS Omega
Yang CW, Hong QA, Weng YH, Yu PJ, Lin BH, Liu CL, Lin YC, Chen WC.   +7 more
europepmc   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source