Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Ta k i n g a n i n - d e p t h l o o k a t : T h e r e l a t i o n s h i p b e t w e e n f o r e i g n l a n g u a g e & c u l t u r e l e a r n i n g a n d s u s t a i n a b l e d e v e l o p m e n t o f Ta i w a n e s e s o c i e t y – t a k i n g c o u r s e s l i k e “ B a s i c F r e n c h ” a n d “ F r e n c h C u l t u r e ” a s a n e x a m p l e . [PDF]
, 2016 [[abstract]]當 全 球 化 成 為 人 類 文 明 發 展 不 可 遏 抑 的 趨 勢 之 後 ， 每 個 國 家 所 面 臨 的第一個重大衝擊是國際語言的溝通障礙， 而每個社會所面臨的第一個 重大議題也是國際語言的學習和應用， 優秀的國際語言人才已成為每個 國家和社會不可或缺的珍稀人力資源。 優 秀 的 國 際 語 言 人 才 不 僅 能 夠 促 進 國 際 間 的 有 效 溝 通 ， 且 因 瞭 解 不 同文化間在本質上的異同之處， 能夠協助本國建構與他國既獨立且相互 ...
S y l v i e A l l a s s o n n i è r e +1 more
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Crystal Structure of Nd(Cd,Si)2 compound [PDF]
, 2002 The crystal structure of the Nd(Cd,Si), compound (C2/m space group, a = 10.969(3) Angstrom, b = 4.061(2) Angstrom c = 7.038(4) Angstrom, beta = 129.05(1)degrees, V = 243.49 Angstrom(3) rho = 7.931 g/cm(3), mu = 29.89 mm(-1).
SALAMAKHA P. +4 more
core +1 more source
Saga Information System Navigator Us E R S Gu I D E F O R C+ + P R O G R A M M E R S
, 2013 The SAGA Service Discovery API provides a way to find grid services matching particular ...
openaire +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
S T ABIL I T AS H ASIL P AD A G E NER ASI S E G REG ASI F 5 , F B E B E RA P A G E NOT I P E K E DEL AI [PDF]
, 2014 The e f for ts to incr e a se th e pr oduc ti on a nd p roduc t ivi t y o f so y be a n that c a n be a c hiev e d throu g h the use of im pr ov ing se e d qua li t y a nd incr ...
F at h u r r ah m an , S P
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Automorphisms of Kronrod-Reeb graphs of Morse functions on 2-sphere
Pracì Mìžnarodnogo Geometričnogo Centru, 2018 Let $M$ be a compact two-dimensional manifold and, $f \in C^{\infty}(M, R)$ be a Morse function, and $\Gamma$ be its Kronrod-Reeb graph. Denote by $O(f)={f o h | h \in D(M)}$ the orbit of $f$ with respect to the natural right action of the group of ...
Anna Kravchenko, Sergiy Maksymenko
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
K a j i a n F i s i o l o g i s B i j i K o p i R o b u s t a D a n A r a b i k a S e l a m a P r o s e s P r a P e r k e c a m b a h a n [PDF]
, 2014 R I N G K A S A N K o p i m e r u p a k a n s a l a h s a t u m i n u m a n y a n g p a l i n g d i s u k a i o l e h s e m u a o r a n g d i d u n i
N i k a H a d i y a R a h m a w a t i
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source