Results 51 to 60 of about 1,231,086 (256)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Patologia sistemica da virus dell'epatite C: la crioglobulinemia mista e altre manifestazioni extraepatiche

Italian Journal of Medicine, 2016
La malattia o sindrome da virus dell’epatite C M. Visconti, R. Nardi Il virus C V. Iovinella, G. Iovinella Crioglobuline, crioglobulinemie e sindromi crioglobulinemiche      M. Visconti, A. Salvio Patogenesi A. Ilardi La vasculite cutanea G.
M. Visconti, M. Campanini, A. Fontanella, R. Nardi, G. Uomo   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Saga Service Discovery Us E R S Gu I D E F O R C+ + P R O G R A M M E R S

, 2013
The SAGA Service Discovery API provides a way to find grid services matching particular ...
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Orthogonal embeddings of graphs in Euclidean space

Electronic Journal of Graph Theory and Applications, 2019
Let G = (V, E) be a simple connected graph. An injective function f : V → Rn is called an n-dimensional (or n-D) orthogonal labeling of G if uv, uw ∈ E implies that (f(v) − f(u)) ⋅ (f(w) − f(u)) = 0, where  ⋅  is the usual dot product in Euclidean space.
Wai Chee Shiu, Richard M. Low
doaj   +1 more source

G\"{o}del-type solution in $f(R,T)$ modified gravity

, 2014
In this paper, we will examine the problem of violation of causality in $f(R,T)$ modified gravity, where $R$ is the Ricci scalar and $T$ is the trace of the energy-momentum tensor $T_{\mu\nu}$. We investigate the causality problem in two special cases, in the first we consider the matter content of the universe as a perfect fluid and in the second case,
Ferst, C. J., Santos, A. F.
openaire   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

P L A C I G O L O I R E T C A B D N A Y T I L A U Q F O G N I R P S D N I R N I K R E T A W G T A A M A T A G T S A E , N W O T A G A L L A W , E N O Z A

, 2023
Advisor: Barsisa Bekele (PHD) A f o e c n e t s i x e e h t r o f n w o n k s e c r u o s e r l a r u t a n l l a f o s t n e m e l e l a i t n e s s e t s o m e h t f o e n o s i r e t a W . h t r a E n o e f i l y r e v e l a r u r n i y l l a i c e p s e , n r e c n o c h t l a e h r o j a m a s i r e t a w g n i k n i r d f o y t i l a u q e h T .
openaire   +2 more sources