Results 61 to 70 of about 1,231,086 (256)

Saga Information System Navigator Us E R S Gu I D E F O R C+ + P R O G R A M M E R S

open access: yes, 2013
The SAGA Service Discovery API provides a way to find grid services matching particular ...
openaire   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

KÖNYVEKRŐL

open access: yesKöz-gazdaság, 2020
Ö S S Z E F O G L A L Ó K A K Ö Z G A Z D A S Á G T U D O M Á N Y I I R O D A L O M B Ó ...
Köz- gazdaság
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Ö S S Z E F O G L A L Ó K A K Ö Z G A Z D A S Á G T U D O M Á N Y I I R O D A L O M B Ó L

open access: yesKöz-gazdaság, 2020
Ö S S Z E F O G L A L Ó K  A   K Ö Z G A Z D A S Á G T U D O M Á N Y I   I R O D A L O M B Ó ...
KÖZ - GAZDASÁG
doaj  

АНАЛИЗ СИСТЕМ ТРУБОПРОВОДНОГО ТРАНСПОРТА САХАРНЫХ ЗАВОДОВ С ЭЛЕМЕНТАМИ АВТОМАТИЧЕСКОГО РЕГУЛИРОВАНИЯ

open access: yesАвтоматизация технологических и бизнес-процессов, 2015
Повышенные требования к качеству сахара и снижения его себестоимости, без больших капитальныхвложений, могут быть обеспечены внедрением систем автоматизации технологических станций сахарногопроизводства и созданием единой системы управления потоками ...
С. А. Володин   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

VARIETY OF GRAY-SCALE SONOGRAPHIC APPEARANCE OF UNTREATED LIVER METASTASES ALI HADIDI [PDF]

open access: yesActa Medica Iranica, 1982
Encountered wit h b izarre patterns o f l i v e r metas t a s es dec l i ned our accuracy rate s o the humi liation o f mist ake s motivated me to re-assess t he value o f hepatic sonography in patients s u spe c t ed o f having metastatic l i ver ...
ALI HADIDI
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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