Results 61 to 70 of about 1,231,086 (256)
Saga Information System Navigator Us E R S Gu I D E F O R C+ + P R O G R A M M E R S
The SAGA Service Discovery API provides a way to find grid services matching particular ...
openaire +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Ö S S Z E F O G L A L Ó K A K Ö Z G A Z D A S Á G T U D O M Á N Y I I R O D A L O M B Ó ...
Köz- gazdaság
doaj
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Ö S S Z E F O G L A L Ó K A K Ö Z G A Z D A S Á G T U D O M Á N Y I I R O D A L O M B Ó L
Ö S S Z E F O G L A L Ó K A K Ö Z G A Z D A S Á G T U D O M Á N Y I I R O D A L O M B Ó ...
KÖZ - GAZDASÁG
doaj
АНАЛИЗ СИСТЕМ ТРУБОПРОВОДНОГО ТРАНСПОРТА САХАРНЫХ ЗАВОДОВ С ЭЛЕМЕНТАМИ АВТОМАТИЧЕСКОГО РЕГУЛИРОВАНИЯ
Повышенные требования к качеству сахара и снижения его себестоимости, без больших капитальныхвложений, могут быть обеспечены внедрением систем автоматизации технологических станций сахарногопроизводства и созданием единой системы управления потоками ...
С. А. Володин +2 more
doaj +1 more source
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
VARIETY OF GRAY-SCALE SONOGRAPHIC APPEARANCE OF UNTREATED LIVER METASTASES ALI HADIDI [PDF]
Encountered wit h b izarre patterns o f l i v e r metas t a s es dec l i ned our accuracy rate s o the humi liation o f mist ake s motivated me to re-assess t he value o f hepatic sonography in patients s u spe c t ed o f having metastatic l i ver ...
ALI HADIDI
doaj +1 more source
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source

