Results 151 to 160 of about 82,705 (288)

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

Brillouin–Raman micro‐mapping of silicone‐hydrogel contact lenses: Revealing chemical and mechanical heterogeneities

Journal of Microscopy, EarlyView.
Abstract Joint Brillouin–Raman micro‐spectroscopy (BRMS) enables simultaneous, non‐destructive characterisation of the mechanical and chemical properties of soft materials at the micrometre scale, combining GHz‐range viscoelastic information from acoustic modes with the vibrational fingerprint of molecular species.
Alessandra Anna Passeri, Martina Alunni Cardinali, Erika Ponzini, Silvia Tavazzi, Daniele Fioretto   +4 more
wiley   +1 more source

Impaired motor unit profile in Fabry disease: A quantitative electrophysiological study. [PDF]

Clin Neurophysiol Pract
Gunduz A, Akkan Suzan A, Dinçer MT, Özcan ŞG, Seyahi N.   +4 more
europepmc   +1 more source

Artefact‐aware Brillouin microscopy framework for root mechanical phenotyping

Journal of Microscopy, EarlyView.
Abstract Plant roots continuously sense and respond to the mechanical signals of their growth environment: root cap function, mucilage secretion, and hormonal regulation jointly adapt root tip mechanics, shaping whether roots penetrate compacted layers or reorient around obstacles. Most current measurements of root mechanical properties require removal
Timm Landes, Ole Christian Hammerschmidt, Leon Pascal Wallentin, Ghulam Naseer Ud Din, Jacob Morsbach, Luis Alonso Baez, Dag Heinemann   +6 more
wiley   +1 more source

Fabry nephropathy as the clinical anchor for kidney-centered metabolic surveillance: linking genetic heterogeneity to early risk identification. [PDF]

Front Genet
Xie Y, Zhong J.
europepmc   +1 more source

Contextual Factors and Intentional Rounding in Acute Hospitals: Understanding What Works, for Whom, in What Settings: A Realist Synthesis

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To synthesise published literature to understand how, when and under what circumstances Intentional Rounding in acute hospital settings improves patient safety and make recommendations for implementation in real‐world settings. Background Inpatient falls often result in injury due to complex interactions between the hospital environment ...
Aileen Hetherton, Jan Sorensen, Frances Horgan, Siobhan McCarthy   +3 more
wiley   +1 more source

Fabry cardiomyopathy presenting as hypertrophic phenotype with left ventricular outflow tract obstruction: a case series. [PDF]

Front Cardiovasc Med
Hosyanto FF, Li Y, Luo S, Huang B.
europepmc   +1 more source

Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy

Topics in Cognitive Science, EarlyView.
Abstract Predictive Processing has been proposed as the single unifying computation underlying all of cognition, and proponents argue that all psychological phenomena can be explained as consequences of this principle. This theoretical framework has inspired many cognitive scientists and neuroscientists, but it currently has no developmental mechanism ...
Emma K. Ward, Danaja Rutar, Lorijn Zaadnoordijk, Francesco Poli, Sabine Hunnius   +4 more
wiley   +1 more source

Occurrence of Infusion Associated Reactions and Antidrug Antibodies in Enzyme Replacement Therapy for Fabry Disease and the Effect of Preventive Measures. [PDF]

J Inherit Metab Dis
Occurrence of infusion associated reactions and anti‐drug antibodies in enzyme replacement therapy for Fabry disease and the effect of preventive measures. ABSTRACT Male patients with the classical phenotype of Fabry disease (FD) are at risk of developing inhibiting antidrug antibodies (iADAs) against recombinant α‐galactosidase‐A, administered in the ...
Janssens M, van der Veen SJ, van Dussen L, van Kuilenburg ABP, Brands MMMG, Langeveld M.   +5 more
europepmc   +2 more sources

Sequential and Concurrent C5 and Neonatal Fc Receptor Inhibition in Prolonged Myasthenic Crisis due to Advanced Invasive Thymoma‐Associated Myasthenia Gravis: A Case Report and Literature Review

Clinical and Experimental Neuroimmunology, Volume 17, Issue 4, November 2026.
ABSTRACT Thymoma‐associated myasthenia gravis (TAMG) is frequently refractory, particularly when complicated by myasthenic crisis in advanced invasive disease. Complement C5 inhibitors and neonatal Fc receptor (FcRn) inhibitors have expanded the treatment of acetylcholine receptor (AChR) antibody‐positive generalized myasthenia gravis; however, their ...
Yuta Kizuka, Yuriko Nakamura, Kensuke Okada, Yu Okubo, Kaoru Kaseda, Hirofumi Toyama, Keisuke Asakura, Atsuya Takeda, Jin Nakahara, Kei Ishizuchi   +9 more
wiley   +1 more source