Results 111 to 120 of about 9,057,553 (322)

Effect of a standardised Ophytrium‐containing shampoo and a leave‐on mousse protocol on dogs with irritated and pruritic skin

Journal of Small Animal Practice, EarlyView.
Objectives Topical formulations are helpful and versatile management modalities for skin disorders. However, veterinary studies assessing their efficacies are limited. This study evaluated the effects of a protocol comprising the combined application of an Ophytrium‐based shampoo and a leave‐on mousse (DOUXO® S3 CALM range) on dogs with irritated and ...
N. Savelli, A. Cozar, M. Abdesselam, E. Ollivier, M. Gatellet, R. Kesteman, P. Fiora, J.‐F. Jamet, V. Mahé, L. Ordeix, T. Blondel, C. Zemirline, X. De Jaeger   +12 more
wiley   +1 more source

Altered pupillary light responses are associated with the severity of autonomic symptoms in patients with Fabry disease

Scientific Reports, 2021
Symptoms of autonomic dysfunction are common in Fabry disease. In this study we aimed to evaluate alterations in the pupillary response to white light stimulation in patients with Fabry disease and their association with the severity of autonomic ...
Gulfidan Bitirgen, Kultigin Turkmen, Nazmi Zengin, Rayaz A. Malik   +3 more
doaj   +1 more source

Enhancing Functional Protein Design Using Heuristic Optimization and Deep Learning for Anti‐Inflammatory and Gene Therapy Applications

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 7, Page 1238-1256, July 2025.
ABSTRACT Protein sequence design is a highly challenging task, aimed at discovering new proteins that are more functional and producible under laboratory conditions than their natural counterparts. Deep learning‐based approaches developed to address this problem have achieved significant success.
Ayşenur Soytürk Patat, Özkan Ufuk Nalbantoğlu   +1 more
wiley   +1 more source

Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study

Journal of Medical Genetics, 2016
Background Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, resulting in α-galactosidase (α-Gal) deficiency and accumulation of lysosomal substrates.
D. Hughes, K. Nicholls, S. Shankar, G. Sunder-Plassmann, D. Koeller, K. Nedd, G. Vockley, T. Hamazaki, R. Lachmann, T. Ohashi, I. Olivotto, N. Sakai, P. Deegan, D. Dimmock, F. Eyskens, D. Germain, O. Goker-Alpan, E. Hachulla, A. Jovanović, C. Lourenço, I. Narita, Mark Thomas, W. Wilcox, D. Bichet, R. Schiffmann, E. Ludington, C. Viereck, J. Kirk, Julie Yu, F. Johnson, P. Boudes, E. Benjamin, D. Lockhart, C. Barlow, N. Skuban, J. Castelli, J. Barth, U. Feldt-Rasmussen   +37 more
semanticscholar   +1 more source

Safety and Tolerability of a Shorter Agalsidase Beta Infusion Time in Patients with Classic or Later-Onset Fabry Disease

Biomedicines
Background: The multisystem manifestations of Fabry disease can create major challenges in patient care. Although enzyme replacement therapy with recombinant agalsidase beta has demonstrated clinical benefits, the standard fortnightly, multi-hour ...
Dominique P. Germain, Alice Porto Vasconcelos, Lien Tran Thi Phuong, Najya Bedreddine, Mihaela Turcan, Wenting Trang, Lynda Barache   +6 more
doaj   +1 more source

Heart failure in two male patients with late‐onset Fabry mutation (IVS4 + 919G > A)

ESC Heart Failure, Volume 12, Issue 2, Page 1508-1513, April 2025.
Xufei Yang, Chunlan Deng, Xiaogang Guo, Hui Yan   +3 more
wiley   +1 more source

Early genetic screening and cardiac intervention in patients with cardiomyopathies in a multidisciplinary clinic

ESC Heart Failure, Volume 12, Issue 3, Page 1942-1955, June 2025.
Abstract Aims Patients with cardiomyopathies are a heterogeneous group of patients who experience high morbidity and mortality. Early cardiac assessment and intervention with access to genetic counselling in a multidisciplinary Cardiomyopathy Clinic may improve outcomes and prevent progression to advanced heart failure.
Chandu Sadasivan, Luke R. Gagnon, Deepan Hazra, Kaiming Wang, Erik Youngson, Jissy Thomas, Anita Y.M. Chan, D. Ian Paterson, Finlay A. McAlister, Tara Dzwiniel, Wayne Tymchak, Susan Christian, Gavin Y. Oudit   +12 more
wiley   +1 more source

Treatment patterns, outcomes and healthcare resource utilization of obstructive hypertrophic cardiomyopathy in England

ESC Heart Failure, Volume 12, Issue 3, Page 2034-2046, June 2025.
Abstract Aims Describe patient characteristics, treatment patterns, clinical outcomes, healthcare resource utilization (HCRU) and medical costs associated with patients who were diagnosed with obstructive hypertrophic cardiomyopathy (HCM) in clinical practice in England.
Faizel Osman, Carla L. Zema, Michael Hurst, Belinda Sandler, Florence Brellier, Ovie Utuama, Oksana Kirichek, John Houghton, Teresa Lemmer, Maite Tome Esteban   +9 more
wiley   +1 more source

Inter-familial and intra-familial phenotypic variability in three Sicilian families with Anderson-Fabry disease. [PDF]

, 2017
BACKGROUND: Anderson-Fabry disease (AFD) is an inborn lysosomal enzymopathy resulting from the deficient or absent activity of the lysosomal exogalactohydrolase, α-galactosidase A.
Colomba P, Corpora F, DAIDONE, Mario, Della Corte V, Di Chiara T, Duro G, Miceli S, Nucera A, Pecoraro R, Pinto A., Scaglione R, Simonetta I, Tuttolomondo A, VOGIATZIS, Danai, Zizzo C   +14 more
core   +1 more source

Cardiac magnetic resonance left atrioventricular coupling index as a prognostic tool in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 3, Page 2177-2189, June 2025.
Abstract Aims A novel marker left atrioventricular coupling index (LACI) has been proved to be associated with cardiovascular events in patients without history of cardiovascular disease. However, the studies on cardiac magnetic resonance‐derived LACI in hypertrophic cardiomyopathy (HCM) patients are limited, and the prognostic value of LACI has still ...
Jinyang Wen, Junhao Tu, Xinwei Tao, Yuanyuan Tang, Zhaoxia Yang, Ziyi Pan, Yi Luo, Chunlin Xiang, Dazhong Tang, Lu Huang, Liming Xia   +10 more
wiley   +1 more source