Protein binding assessment of immobilized nanobody using interferometric nanoporous platform
VIEW, EarlyView.Nanoporous anodic alumina photonic chip technology is combined with tailor‐engineered “nanobodies”—recombinant variable domains of heavy‐chain‐only antibodies—to achieve high affinity binding to human serum albumin. Abstract Protein sensors are key tools for infectious disease diagnosis and monitoring.
Cheryl Suwen Law +6 more
wiley +1 more source
Long-term enzyme replacement therapy is associated with reduced proteinuria and preserved proximal tubular function in women with Fabry disease [PDF]
, 2017 Background Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the GLA gene. Deficiency of α-galactosidase A (α-Gal A) causes intracellular accumulations of globotriaosylceramide (GL-3) and related glycosphingolipids in all ...
Bibby, Bo M. +7 more
core
Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications [PDF]
, 2017 The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase.
Ahmed, S. Faisal +4 more
core +1 more source
Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy
Topics in Cognitive Science, EarlyView.Abstract Predictive Processing has been proposed as the single unifying computation underlying all of cognition, and proponents argue that all psychological phenomena can be explained as consequences of this principle. This theoretical framework has inspired many cognitive scientists and neuroscientists, but it currently has no developmental mechanism ...
Emma K. Ward +4 more
wiley +1 more source
Fabryjeva bolest - smjernice za dijagnozu i liječenje odraslih bolesnika [Fabry disease - guidelines for diagnosis and management of adult patients] [PDF]
, 2014 Early diagnosis and management of patients with Fabry disease (FD) requires a multidisciplinary approach of several different experts. The aim of this document is to provide health care professionals with guidelines for management of adult patients with ...
Merkler, Marijan +5 more
core
Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy. [PDF]
, 2015 Background: Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder characterized by unexplained left ventricle hypertrophy associated with non-dilated ventricular chambers.
BOTTILLO, IRENE +12 more
core +1 more source
Heart failure in two male patients with late‐onset Fabry mutation (IVS4 + 919G > A)
ESC Heart Failure, Volume 12, Issue 2, Page 1508-1513, April 2025.
Xufei Yang +3 more
wiley +1 more source
Measurement and control of mechanics of cardiac trabeculae secured by light‐curable hydrogel
Experimental Physiology, EarlyView.Abstract Isolated cardiac trabeculae are small heart muscle tissue preparations, which have been widely used in in vitro studies of mechanics and energetics function of cardiac muscle. Current instruments for such experimentation often (1) involve delicate mounting of the muscle, (2) constrain investigations to one muscle at a time, and thus (3) limit ...
Emily J. Clark Murphy +6 more
wiley +1 more source
Legg-Calvé-Perthes disease and the risk of injuries requiring hospitalization [PDF]
, 2012 Background and purpose Previous studies have suggested that Legg-Calvé-Perthes disease (LCPD) is associated with repetitive trauma, coagulation problems and anatomical abnormalities of the blood supply to the femoral head. The hypothesis that repetitive
Bahmanyar, S. +4 more
core +1 more source
Journal of Genetic Counseling, Volume 35, Issue 1, February 2026.Abstract Logotherapy is a psychological approach originated by Viktor Frankl, shaped by the thesis that meaning can be discovered even in the most tragic of human circumstances, and through a human's will‐to‐meaning, that individuals have both freedom and responsibility to discover meanings in the moment and ultimate meanings from their unique ...
Nour Chanouha +5 more
wiley +1 more source