Results 81 to 90 of about 9,220,596 (237)

Will biodiversity actions yield healthy places? A systematic review of human health outcomes associated with biodiversity‐focused urban greening

People and Nature, EarlyView.
Abstract There is growing interest in using urban greening projects to support biodiversity. While there are many potential co‐benefits, the health outcomes resulting from biodiversity‐supporting activities have yet to be synthesized. We conducted a systematic review of health outcomes associated with seven biodiversity‐supporting elements, including ...
Erica N. Spotswood, Myla Aronson, Micaela Bazo, Erin Beller, J. D. Brown, Iryna Dronova, Cesar O. Estien, Howard Frumkin, Joseph Galarraga, Robin Grossinger, Kim Hachadoorian, Brandon Herman, Thomas Jennings, Viniece Jennings, Ming Kuo, Robert I. McDonald, Daphne Miller, Alessandro Rigolon, Jennifer Symonds, Karen Weinbaum   +19 more
wiley   +1 more source

Heart failure in two male patients with late‐onset Fabry mutation (IVS4 + 919G > A)

ESC Heart Failure, Volume 12, Issue 2, Page 1508-1513, April 2025.
Xufei Yang, Chunlan Deng, Xiaogang Guo, Hui Yan   +3 more
wiley   +1 more source

Regenerating the Senses: Stem Cell‐Derived Sensory Neurons and Functional Genomics in Neurological Disorders

Sensory Neuroscience, EarlyView.
ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan, Avanthika Nityanand, Anjali Pandit, Vaishnavi Gururajan   +3 more
wiley   +1 more source

Aging Reduces Intestinal Stem Cell Activity in Killifish and Intermittent Fasting Reverses Intestinal Gene Expression Patterns

Aging Cell, EarlyView.
Intestinal stem cells occur in clusters, and the cycle time of stem cells increases with age. The age‐dependent decline in structural intestinal tissue homeostasis is associated with a decline in stem cell activity. Aging causes significant changes in intestinal gene expression; intermittent fasting from adulthood onwards results in a gene expression ...
Michael Kothmayer, Sylvia Laffer, Philipp Widmayer, Elmar E. Ebner, Fehima Ugarak, David Martin, Stefan H. Geyer, Kareem Elsayad, Wolfgang J. Weninger, Sabine Lagger, Klara Weipoltshammer, Oliver Pusch, Christian Schöfer   +12 more
wiley   +1 more source

Modelling Fabry disease with kidney organoids derived from human embryonic stem cells using CRISPR-Cas9 mediated gene editing [PDF]

Organoid
Background Fabry disease, a rare genetic disorder, arises from mutations in the α-galactosidase A gene (GLA), leading to Gb3 accumulation and multi-organ damage.
Su Jeong Lee, Kyung Jin Lee, Joo Hyun Jee, Hyokyung Lee, Lina Joo, Woo Hee Choi, Jongman Yoo, Hye Yun Jeong   +7 more
doaj   +1 more source

Oral Chaperone Therapy Migalastat for Treating Fabry Disease: Enzymatic Response and Serum Biomarker Changes After 1 Year

Clinical pharmacology and therapy, 2019
Long‐term effects of migalastat therapy in clinical practice are currently unknown. We evaluated migalastat efficacy and biomarker changes in a prospective, single‐center study on 14 patients with Fabry disease (55 ± 14 years; 11 men).
Jonas Müntze, D. Gensler, O. Maniuc, Dan Liu, T. Cairns, D. Oder, K. Hu, K. Lorenz, S. Frantz, C. Wanner, P. Nordbeck   +10 more
semanticscholar   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Come from away: Reconstructing a long‐range migratory flight of spruce budworm moths to Newfoundland, Canada Venues de loin : reconstitution d'un vol migratoire de longue distance de tordeuses des bourgeons de l'épinette vers Terre‐Neuve, au Canada

Ecological Entomology, EarlyView.
Lagrangian atmospheric models were used in conjunction with ecophysiological factors to reconstruct the path and meteorological conditions of a long‐range migration flight of spruce budworm moths to Newfoundland, Canada. Moths travelled under high winds and warm temperatures that favoured their migratory flight until encountering cooler temperatures ...
Philippe Barnéoud, Jennie Pearce, Alain Malo, Jean‐Noël Candau   +3 more
wiley   +1 more source

Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study

Journal of Medical Genetics, 2016
Background Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, resulting in α-galactosidase (α-Gal) deficiency and accumulation of lysosomal substrates.
D. Hughes, K. Nicholls, S. Shankar, G. Sunder-Plassmann, D. Koeller, K. Nedd, G. Vockley, T. Hamazaki, R. Lachmann, T. Ohashi, I. Olivotto, N. Sakai, P. Deegan, D. Dimmock, F. Eyskens, D. Germain, O. Goker-Alpan, E. Hachulla, A. Jovanović, C. Lourenço, I. Narita, Mark Thomas, W. Wilcox, D. Bichet, R. Schiffmann, E. Ludington, C. Viereck, J. Kirk, Julie Yu, F. Johnson, P. Boudes, E. Benjamin, D. Lockhart, C. Barlow, N. Skuban, J. Castelli, J. Barth, U. Feldt-Rasmussen   +37 more
semanticscholar   +1 more source

Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy

Topics in Cognitive Science, EarlyView.
Abstract Predictive Processing has been proposed as the single unifying computation underlying all of cognition, and proponents argue that all psychological phenomena can be explained as consequences of this principle. This theoretical framework has inspired many cognitive scientists and neuroscientists, but it currently has no developmental mechanism ...
Emma K. Ward, Danaja Rutar, Lorijn Zaadnoordijk, Francesco Poli, Sabine Hunnius   +4 more
wiley   +1 more source