Results 81 to 90 of about 4,907,795 (224)

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy

Topics in Cognitive Science, EarlyView.
Abstract Predictive Processing has been proposed as the single unifying computation underlying all of cognition, and proponents argue that all psychological phenomena can be explained as consequences of this principle. This theoretical framework has inspired many cognitive scientists and neuroscientists, but it currently has no developmental mechanism ...
Emma K. Ward, Danaja Rutar, Lorijn Zaadnoordijk, Francesco Poli, Sabine Hunnius   +4 more
wiley   +1 more source

Modelling Fabry disease with kidney organoids derived from human embryonic stem cells using CRISPR-Cas9 mediated gene editing [PDF]

Organoid
Background Fabry disease, a rare genetic disorder, arises from mutations in the α-galactosidase A gene (GLA), leading to Gb3 accumulation and multi-organ damage.
Su Jeong Lee, Kyung Jin Lee, Joo Hyun Jee, Hyokyung Lee, Lina Joo, Woo Hee Choi, Jongman Yoo, Hye Yun Jeong   +7 more
doaj   +1 more source

Heart failure in two male patients with late‐onset Fabry mutation (IVS4 + 919G > A)

ESC Heart Failure, Volume 12, Issue 2, Page 1508-1513, April 2025.
Xufei Yang, Chunlan Deng, Xiaogang Guo, Hui Yan   +3 more
wiley   +1 more source

Non-specific gastrointestinal features: Could it be Fabry disease?

, 2018
Non-specific gastrointestinal symptoms, including pain, diarrhoea, nausea, and vomiting, can be the first symptoms of Fabry disease. They may suggest more common disorders, e.g. irritable bowel syndrome or inflammatory bowel disease.
Gasbarrini A., Spada, Marina, Manna R.
core   +2 more sources

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, Volume 101, Issue 5, Page 2408-2426, October 2026.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

Shared Decision‐Making and Patient Enablement in Outpatient Rehabilitation: An Observational Study

Physiotherapy Research International, Volume 31, Issue 4, October 2026.
ABSTRACT Objectives To examine the association between shared decision‐making (SDM) and patient enablement in outpatient rehabilitation consultations. Methods In this observational cross‐sectional study, 158 patients attending outpatient rehabilitation at four facilities in Japan were assessed, of whom 93 were included in the final analyses ...
Naoto Iwasawa, Shota Hori, Hitoshi Fujita, Takuya Yamada, Hirono Ishikawa   +4 more
wiley   +1 more source

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies

International Journal of Cancer, Volume 159, Issue 6, Page 1360-1384, 15 September 2026.
ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg, Alyssa R. Russum, Matthew R. Sandbulte, Eleanor G. Rogan, Martha G. Rhoades   +4 more
wiley   +1 more source

Axially symmetrical Fabry-Perot oscillator with multiple devices inserted in dielectric substrate [PDF]

, 1997
We investigate an axially symmetrical Fabry-Perot oscillator with active devices inserted in a dielectric substrate for power combining of many more devices in the microwave and millimeter wave frequency range.
Sanagi, Minoru, S. Nogi, Nogi, Shigeji, M. Sanagi, Itoga, Toshihide, T. Itoga   +5 more
core   +1 more source

Planar micromachined glass cantilevers utilising integrated Bragg Fabry-Perot cavities

, 2010
Here we demonstrate a glass cantilever based on a unique micromachining and etching approach, combined with UV written Bragg gratings. We shall also discuss the increase in sensitivity by using two Bragg gratings to form Fabry-Pérot cavity.
Carpenter, Lewis, Gates, James C., Smith, Peter G.R., Holmes, Christopher   +3 more
core   +1 more source