Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Dynamic evolution of bed separation volume and strata migration in coal seam groups under repeated mining. [PDF]
Sci RepLi B, Wang H, Li L, Guo W, Tian J.
europepmc +1 more source
The Aesthetic Triangle in the Arrangement of Teeth: Face Form, tooth Form, and Alignment Form, Harmonious or Grotesque [PDF]
, 1922 A. Alfred Nelson
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The effect of emotional expression on age estimates is modulated by face age and participant age. [PDF]
BMC PsycholJi L, Liao S, Hayward WG.
europepmc +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Mapping macaque to human cortex with natural scene responses. [PDF]
Proc Natl Acad Sci U S AVinken K, Sharma S, Livingstone MS.
europepmc +1 more source
THE CORRECTION OF ANKYLOSIS OF THE JAW AND ASSOCIATED DEFORMITIES OF THE FACE
, 1951 KENNETH PICKRELL +4 more
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