Results 201 to 210 of about 392,904 (260)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source
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Detecting Faces With Face Masks

2021 44th International Conference on Telecommunications and Signal Processing (TSP), 2021
This paper deals with the evaluation of several methods for face detection when the face is covered by a mask. The methods evaluated are Haar cascade and Histogram of Oriented Gradients as feature-based approaches, Multitask Cascade Convolutional Neural Network, Max Margin Object Detection and TinyFace as convolutional neural network based approaches ...
Jiri Prinosil, Ondrej Maly
openaire   +1 more source

Face Detection: A Survey

Computer Vision and Image Understanding, 2001
Summary: We present a comprehensive and critical survey of face detection algorithms. Face detection is a necessary first-step in face recognition systems, with the purpose of localizing and extracting the face region from the background. It also has several applications in areas such as content-based image retrieval, video coding, video conferencing ...
Erik Hjelmås, Boon Kee Low
exaly   +3 more sources

Detection of Fatigued Face

2021 2nd International Conference on Control, Robotics and Intelligent System, 2021
For some large and complex operating platforms in machinery factories, in order to detect fatigued workers in time, machine vision is adopted for fatigue detection. Normal camera cannot cover the entire working range. So come up with an idea to use an industrial computer to control the pan-tilt for face tracking and fatigue detection.
Ming-da Song   +3 more
openaire   +1 more source

Dominance detection in face-to-face conversations

2009 IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops, 2009
Dominance is referred to the level of influence a person has in a conversation. Dominance is an important research area in social psychology, but the problem of its automatic estimation is a very recent topic in the contexts of social and wearable computing. In this paper, we focus on dominance detection from visual cues.
Sergio Escalera   +4 more
openaire   +1 more source

A Face Detection Based on Face Features

2009
Face detection is a key problem in intelligent visual human computer interaction research. It is essential to many applications, for example, human face synthesis, face recognition, face tracking, pose estimation, facial expression recognition and object oriented image coding.
Hanmin Huang, Gang Hu
openaire   +1 more source

Heterogeneous Face Detection

Proceedings of the International Conference on Internet of things and Cloud Computing, 2016
Face detection is the process of determining the location of human faces in an image. Like human visual system, a face detection system should also be capable of achieving the detection task irrespective of illumination, absence of texture, orientation and camera distance.
Akanksha Das   +2 more
openaire   +1 more source

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