Results 31 to 40 of about 145,741 (259)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Recovering Faces from Portraits with Auxiliary Facial Attributes

, 2019
Recovering a photorealistic face from an artistic portrait is a challenging task since crucial facial details are often distorted or completely lost in artistic compositions.
Hartley, Richard, Koniusz, Piotr, Porikli, Fatih, Shiri, Fatemeh, Yu, Xin   +4 more
core   +1 more source

Multi-Scale Feature Channel Attention Generative Adversarial Network for Face Sketch Synthesis

IEEE Access, 2020
Face sketch synthesis for photos is an applied research topic and it is critical for criminal investigation. However, sketch synthesis remains some challenges because of the blur and artifacts in the generated face sketches. To mitigate these problems in
Jieying Zheng, Yahong Wu, Wanru Song, Ran Xu, Feng Liu   +4 more
semanticscholar   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Deep Sketch-Photo Face Recognition Assisted by Facial Attributes

, 2018
In this paper, we present a deep coupled framework to address the problem of matching sketch image against a gallery of mugshots. Face sketches have the essential in- formation about the spatial topology and geometric details of faces while missing some ...
Dabouei, Ali, Iranmanesh, Seyed Mehdi, Kazemi, Hadi, Nasrabadi, Nasser M., Soleymani, Sobhan   +4 more
core   +1 more source

Face Photo-Sketch Synthesis and Recognition

International Journal of Applied Information Systems, 2012
Today in Modern Society Face Recognition has gained much attention in the field of network multimedia access. After the 9/11 tragedy in India, the need for technologies for identification, detection and recognition of suspects has increased. One of the most common biometric recognition techniques is face recognition since face is the convenient way ...
Prakash R. Devale, Amit R.Sharma
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

3D Shape Reconstruction from Sketches via Multi-view Convolutional Networks

, 2017
We propose a method for reconstructing 3D shapes from 2D sketches in the form of line drawings. Our method takes as input a single sketch, or multiple sketches, and outputs a dense point cloud representing a 3D reconstruction of the input sketch(es). The
Gadelha, Matheus, Kalogerakis, Evangelos, Lun, Zhaoliang, Maji, Subhransu, Wang, Rui   +4 more
core   +1 more source