Results 91 to 100 of about 809,490 (287)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Facial Communicative Signal Interpretation in Human-Robot Interaction by Discriminative Video Subsequence Selection [PDF]

, 2012
Lang C, Wachsmuth S, Hanheide M, Wersing H. Facial Communicative Signal Interpretation in Human-Robot Interaction by Discriminative Video Subsequence Selection.; 2012.Facial communicative signals (FCSs) such as head gestures, eye gaze, and facial ...
Wersing, Heiko, Lang, Christian, Christian Lang, Heiko Wersing, Hanheide, Marc, Marc Hanheide, Wachsmuth, Sven ; https://orcid.org/, Sven Wachsmuth   +7 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Chimpanzees (Pan troglodytes) produce the same types of ‘laugh faces’ when they emit laughter and when they are silent [PDF]

, 2015
The ability to flexibly produce facial expressions and vocalizations has a strong impact on the way humans communicate, as it promotes more explicit and versatile forms of communication. Whereas facial expressions and vocalizations are unarguably closely
Davila-Ross, Marina, Jesus, Goncalo, Marina Davila-Ross (752759), Goncalo Jesus (752760), Jade Osborne (752761), Bard, Kim A., Osborne, Jade, Marina Davila-Ross, Jade Osborne, Goncalo Jesus, Kim A Bard, Kim A. Bard (752762)   +11 more
core   +2 more sources

Misrecognition of facial expressions in delinquents

Child and Adolescent Psychiatry and Mental Health, 2009
Background Previous reports have suggested impairment in facial expression recognition in delinquents, but controversy remains with respect to how such recognition is impaired.
Matsuura Naomi, Uono Shota, Sato Wataru, Toichi Motomi   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Facial expressions in response to a highly surprising event exceeding the field of vision: a test of Darwin's theory of surprise [PDF]

, 2012
Copyright © 2012 Elsevier Inc. All rights reserved.According to the affect program theory of facial displays, the evolutionary core of the human emotion system consists of a small set of discrete emotion mechanisms that comprise motor programs for ...
Schützwohl, A, Reisenzein, R
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A Specific Association between Facial Disgust Recognition and Estradiol Levels in Naturally Cycling Women. [PDF]

, 2015
Subtle changes in social cognition are associated with naturalistic fluctuations in estrogens and progesterone over the course of the menstrual cycle.
H. Valerie Curran (724366), Sunjeev K. Kamboj (724364), H Valerie Curran, Kathleen M. Krol (724365), Curran, H., Kathleen M Krol, Curran H. Valerie, Krol, KM, Curran, HV, Krol, K., Kamboj Sunjeev K., Kamboj, SK, Kamboj, S., Krol Kathleen M., Sunjeev K Kamboj   +14 more
core   +2 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source