Results 111 to 120 of about 352,635 (287)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

Facial Landmark Detection and Head Pose Estimation of Occluded Faces Based on Stable Diffusion Image Completion

open access: yesIEEE Access
Face occlusion often makes it challenging to detect facial landmarks and head pose accurately. In this work, we present a pipeline to estimate facial landmarks and head pose when only a partial face is visible.
Wenzhangzhi Guo   +4 more
doaj   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

open access: yesAdvanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu   +12 more
wiley   +1 more source

Automated analysis of emotional expressions in dogs based on geometric morphometrics

open access: yesScientific Reports
Automated analysis of facial expressions is a vibrant field in human affective computing, while research in nonhuman animals is still in its early stages.
George Martvel, Stefanie Riemer
doaj   +1 more source

3D Facial scan with annotated landmarks.

open access: yes, 2016
3D facial mesh obtained for each study individual with study landmarks obtained from automatic landmarking overlaid and labeled.
Emmanuel Kimwaga (3080718)   +18 more
core   +1 more source

Tri‐Functional Electrocatalysis for Zinc–Air Battery Coupled Water Splitting: A Catalyst‐Electrode‐Device‐System Perspective

open access: yesAdvanced Science, EarlyView.
This review establishes a catalyst–electrode–device–system framework for tri‐functional HER/OER/ORR electrocatalysis that couples water splitting with Zn–air batteries. Five catalyst families are covered: noble‐metal, metal‐based, single‐atom, heterostructure, and metal‐free systems.
Xixi Di   +9 more
wiley   +1 more source

Accuracy of cephalometric landmark and cephalometric analysis from lateral facial photograph by using CNN-based algorithm

open access: yesScientific Reports
Cephalometric analysis is the primary diagnosis method in orthodontics. In our previous study, the algorithm was developed to estimate cephalometric landmarks from lateral facial photographs of patients with normal occlusion.
Yui Shimamura   +6 more
doaj   +1 more source

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